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- W2785129105 abstract "Background: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, polymorphisms in the apoE gene have been associated with an increased relative risk of coronary artery disease (CAD).Objective: To determine whether or not the apoE gene increases the risk of heart blood stasis syndrome (HBSS) in premature coronary heart disease (PCHD) pedigrees.Methods: Twenty-eight core pedigrees with PCHD and HBSS were collected. The apoEe2/e3/e4 genotype was measured using a PCR-RFLP technique. HHRR and TDT were used with core pedigrees based on the result that the apoE polymorphism was linked with PCHD.Results: According to HHRR, the apoE e4 allele may be associated with PCHD with HBSS (P<0.05). According to the TDT test, the susceptibility loci of CHD with HBSS may be linked to the apoE e4 allele (P<0.01).Conclusions: The apoE e4 gene polymorphism in PCHD and HBSS pedigrees associated with coronary heart disease, and coronary heart disease susceptibility loci may be linked with apoE e4 alleles, which indicates that the apoE gene may be linked to the susceptibility location of HBSS in CHD within the Hunan han nation population." @default.
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- W2785129105 date "2017-01-01" @default.
- W2785129105 modified "2023-09-25" @default.
- W2785129105 title "Association between apolipoprotein E gene and heart blood stasis syndrome in premature coronary heart disease pedigrees within the Hunan han nation population" @default.
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