FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785148966> ?p ?o ?g. }

• W2785148966 endingPage "4787" @default.
• W2785148966 startingPage "4787" @default.
• W2785148966 abstract "Abstract Background: Donor erythrocyte (RBC) transfusion was the first therapy used in sickle cell disease (SCD) that targets the pathophysiology of sickle cell disease.1 Transfused RBCs represent iron that circumvents the normal pathways of iron regulation, this excess iron accumulates in tissues.2 Iron overload was present in one third of 141 adult SCD patients at post mortem (mean age, 36 years) and 7% of deaths were related to iron overload.3 In a cohort of 387 young adults from Atlanta, there were 22 deaths, 45% related to iron overload (cirrhosis: 9, heart failure: 2).4 The frequency of hospital admission increased with increased serum ferritin in 199 transfused SCD patients, although the extent to which iron overload was a cause or a consequence of disease severity was not clear.5 We designed a study to retrospectively review the clinical course of SCD patients with iron overload compared to those without iron overload. Methods: We retrospectively reviewed 105 patients at the sickle cell comprehensive clinic at the study institution from Jan 1, 1998 to Oct 31, 2016. Patients with Hb SS, HSC and HB S beta0thalassemia were included. Iron overload was defined as mean serum ferritin >1000 ng/ml and/or T2 liver MRI with hepatic iron content >3 mg/g dry weight. Clinical outcomes studied as categorical variables were liver disease - defined as hepatomegaly, coagulopathy, signs of portal HTN or cirrhosis, thyroid disease - symptoms or abnormal thyroid functions, hypogonadism - history or laboratory measurement of gonadotrophins, arthropathy - symptoms or radiological evidence of joint disease and congestive heart failure - symptoms or low left ventricular ejection fraction on echocardiogram. Clinical outcomes that were studied as continuous variables were number of hospitalization during study period and mean body mass index. Patients who were on chelation at any time were analyzed separately as a subgroup within the iron overload cohort. The categorical variables were analyzed by using Chi-Square test and numerical variable was analyzed using t-test for equality of means. Results: 86 out of 105 patients had complete data for clinical outcomes. Out of 33 patients with iron overload 22 had liver disease (66.7%) as compared to only 20 out of 53 (37.7%) without iron overload (p-value =0.009 which was significant). Out of 31 patients with iron overload only 2 (6.5%) had thyroid disease as compared to 0 out of 53 patients (0%) without iron overload. Out of 30 patients with iron overload 0 (0%) had hypogonadism as compared to 3 out of 50 patients (6%) without iron overload. 5 out of 33 patients with iron overload (15.2%) had arthropathy as compared to 5 out of 53 without iron overload (9.4%). 4 out of 31 patients with iron overload had congestive heart failure (12.9%) compared to 3 out of 50 patients without iron overload (6.0%). A total of 10 out of 33 patients (30.3%) with iron overload got chelation at some time during the study period. 8 out of 10 patients (80%) with iron overload who got chelation had liver disease compared to 14 out of 23 patients (60%) with iron overload and no chelation. 2 out 10 patients (20%) who got chelation had thyroid disease compared to 0 out of 21 (0%) without chelation. Interestingly, 4 out of 10 patients (40%) who got chelation had arthropathy compared to 1 out of 23 (4.3%) without chelation (p-value = 0.021 which was significant). 3 out of 9 patients (33.3%) who got chelation had congestive heart failure compared to 1 out of 22 patients (4.5%) without chelation. The mean number of hospitalizations in the iron overload group was 32.07 vs 21.74 in the non-iron overload group during the study period (p-value = 0.169). The mean BMI was 24.59 in the iron overload group compared to 28.48 in the non-iron overload group (p-value = 0.021 was significant). Conclusion: Iron overload was associated with significantly more incidence of liver disease in SCD patients. Chelation was not associated with a statistical significant difference on the incidence of liver disease in the iron overload cohort. There was no significant differences observed in congestive heart failure, hypogonadism or arthropathy. However, patients who were chelated did have a significantly higher incidence of arthropathy. There was no statistically significant difference in the number of hospitalization. Patients with iron overload did have a statistical significant association with having lower BMI. Download : Download high-res image (175KB) Download : Download full-size image Disclosures No relevant conflicts of interest to declare." @default.
• W2785148966 created "2018-02-02" @default.
• W2785148966 creator A5008355882 @default.
• W2785148966 creator A5027312912 @default.
• W2785148966 creator A5029219899 @default.
• W2785148966 creator A5038592214 @default.
• W2785148966 creator A5039722640 @default.
• W2785148966 creator A5048608587 @default.
• W2785148966 creator A5052554397 @default.
• W2785148966 creator A5055978130 @default.
• W2785148966 creator A5067624582 @default.
• W2785148966 creator A5089483487 @default.
• W2785148966 date "2017-12-07" @default.
• W2785148966 modified "2023-09-26" @default.
• W2785148966 title "Clinical Impact of Iron Overload on Morbidity in Patients with Sickle Cell Disease" @default.
• W2785148966 doi "https://doi.org/10.1182/blood.v130.suppl_1.4787.4787" @default.
• W2785148966 hasPublicationYear "2017" @default.
• W2785148966 type Work @default.
• W2785148966 sameAs 2785148966 @default.
• W2785148966 citedByCount "0" @default.
• W2785148966 crossrefType "journal-article" @default.
• W2785148966 hasAuthorship W2785148966A5008355882 @default.
• W2785148966 hasAuthorship W2785148966A5027312912 @default.
• W2785148966 hasAuthorship W2785148966A5029219899 @default.
• W2785148966 hasAuthorship W2785148966A5038592214 @default.
• W2785148966 hasAuthorship W2785148966A5039722640 @default.
• W2785148966 hasAuthorship W2785148966A5048608587 @default.
• W2785148966 hasAuthorship W2785148966A5052554397 @default.
• W2785148966 hasAuthorship W2785148966A5055978130 @default.
• W2785148966 hasAuthorship W2785148966A5067624582 @default.
• W2785148966 hasAuthorship W2785148966A5089483487 @default.
• W2785148966 hasConcept C126322002 @default.
• W2785148966 hasConcept C2776590208 @default.
• W2785148966 hasConcept C2777075537 @default.
• W2785148966 hasConcept C2777214474 @default.
• W2785148966 hasConcept C2778248108 @default.
• W2785148966 hasConcept C2778319317 @default.
• W2785148966 hasConcept C2779134260 @default.
• W2785148966 hasConcept C2780622394 @default.
• W2785148966 hasConcept C2780883591 @default.
• W2785148966 hasConcept C71924100 @default.
• W2785148966 hasConcept C90924648 @default.
• W2785148966 hasConceptScore W2785148966C126322002 @default.
• W2785148966 hasConceptScore W2785148966C2776590208 @default.
• W2785148966 hasConceptScore W2785148966C2777075537 @default.
• W2785148966 hasConceptScore W2785148966C2777214474 @default.
• W2785148966 hasConceptScore W2785148966C2778248108 @default.
• W2785148966 hasConceptScore W2785148966C2778319317 @default.
• W2785148966 hasConceptScore W2785148966C2779134260 @default.
• W2785148966 hasConceptScore W2785148966C2780622394 @default.
• W2785148966 hasConceptScore W2785148966C2780883591 @default.
• W2785148966 hasConceptScore W2785148966C71924100 @default.
• W2785148966 hasConceptScore W2785148966C90924648 @default.
• W2785148966 hasLocation W27851489661 @default.
• W2785148966 hasOpenAccess W2785148966 @default.
• W2785148966 hasPrimaryLocation W27851489661 @default.
• W2785148966 hasRelatedWork W101480242 @default.
• W2785148966 hasRelatedWork W1987287496 @default.
• W2785148966 hasRelatedWork W2010918421 @default.
• W2785148966 hasRelatedWork W2219268135 @default.
• W2785148966 hasRelatedWork W2363581739 @default.
• W2785148966 hasRelatedWork W2406989395 @default.
• W2785148966 hasRelatedWork W2414606905 @default.
• W2785148966 hasRelatedWork W2466519097 @default.
• W2785148966 hasRelatedWork W2515232442 @default.
• W2785148966 hasRelatedWork W2568905249 @default.
• W2785148966 hasRelatedWork W2573455821 @default.
• W2785148966 hasRelatedWork W2582129105 @default.
• W2785148966 hasRelatedWork W2648342512 @default.
• W2785148966 hasRelatedWork W2979330931 @default.
• W2785148966 hasRelatedWork W2997454660 @default.
• W2785148966 hasRelatedWork W3101350217 @default.
• W2785148966 hasRelatedWork W3154168099 @default.
• W2785148966 hasRelatedWork W3209419046 @default.
• W2785148966 hasRelatedWork W640752109 @default.
• W2785148966 hasRelatedWork W2741519865 @default.
• W2785148966 hasVolume "130" @default.
• W2785148966 isParatext "false" @default.
• W2785148966 isRetracted "false" @default.
• W2785148966 magId "2785148966" @default.
• W2785148966 workType "article" @default.