FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785181837> ?p ?o ?g. }

• W2785181837 abstract "Transient receptor potential ankyrin 1 (TRPA1) is a temperature-sensitive ion channel activated by various pungent and irritant compounds that can produce pain in humans. Its activation involves an allosteric mechanism whereby electrophilic agonists evoke interactions within cytosolic domains and open the channel pore through an integrated nexus formed by intracellular membrane proximal regions that are densely packed beneath the lower segment of the S1-S4 sensor domain. Studies indicate that this part of the channel may contain residues that form a water-accessible cavity that undergoes changes in solvation during channel gating. We identified conserved polar residues facing the putative lower crevice of the sensor domain that were crucial determinants of the electrophilic, voltage, and calcium sensitivity of the TRPA1 channel. This part of the sensor may also comprise a domain capable of binding to membrane phosphoinositides through which gating of the channel is regulated in a state-dependent manner." @default.
• W2785181837 created "2018-02-02" @default.
• W2785181837 creator A5002271830 @default.
• W2785181837 creator A5006117015 @default.
• W2785181837 creator A5014788936 @default.
• W2785181837 creator A5041325691 @default.
• W2785181837 creator A5045559519 @default.
• W2785181837 creator A5065970835 @default.
• W2785181837 creator A5082273690 @default.
• W2785181837 date "2018-01-23" @default.
• W2785181837 modified "2023-10-14" @default.
• W2785181837 title "Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel" @default.
• W2785181837 cites W1551810886 @default.
• W2785181837 cites W183810266 @default.
• W2785181837 cites W1917163647 @default.
• W2785181837 cites W1964235591 @default.
• W2785181837 cites W1971391513 @default.
• W2785181837 cites W1972003023 @default.
• W2785181837 cites W1973796039 @default.
• W2785181837 cites W1976499671 @default.
• W2785181837 cites W1984533345 @default.
• W2785181837 cites W1984790349 @default.
• W2785181837 cites W2001294652 @default.
• W2785181837 cites W2011067868 @default.
• W2785181837 cites W2015307577 @default.
• W2785181837 cites W2019123717 @default.
• W2785181837 cites W2021052871 @default.
• W2785181837 cites W2022964566 @default.
• W2785181837 cites W2027408247 @default.
• W2785181837 cites W2029667189 @default.
• W2785181837 cites W2039558245 @default.
• W2785181837 cites W2048830609 @default.
• W2785181837 cites W2054799935 @default.
• W2785181837 cites W2058479011 @default.
• W2785181837 cites W2066063983 @default.
• W2785181837 cites W2074252493 @default.
• W2785181837 cites W2084307938 @default.
• W2785181837 cites W2094879588 @default.
• W2785181837 cites W2098210944 @default.
• W2785181837 cites W2106140689 @default.
• W2785181837 cites W2110156846 @default.
• W2785181837 cites W2118212514 @default.
• W2785181837 cites W2118612841 @default.
• W2785181837 cites W2120229762 @default.
• W2785181837 cites W2131777290 @default.
• W2785181837 cites W2132629607 @default.
• W2785181837 cites W2150981663 @default.
• W2785181837 cites W2158266834 @default.
• W2785181837 cites W2164659462 @default.
• W2785181837 cites W2168133993 @default.
• W2785181837 cites W2171958789 @default.
• W2785181837 cites W2240558284 @default.
• W2785181837 cites W2301186499 @default.
• W2785181837 cites W2323300135 @default.
• W2785181837 cites W2332712348 @default.
• W2785181837 cites W2340981781 @default.
• W2785181837 cites W2404622021 @default.
• W2785181837 cites W2416429243 @default.
• W2785181837 cites W2467502628 @default.
• W2785181837 cites W2532016379 @default.
• W2785181837 cites W2566371524 @default.
• W2785181837 cites W2576388396 @default.
• W2785181837 cites W2582320899 @default.
• W2785181837 cites W2603008385 @default.
• W2785181837 cites W2684441367 @default.
• W2785181837 cites W4243927500 @default.
• W2785181837 doi "https://doi.org/10.1126/scisignal.aan8621" @default.
• W2785181837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29363587" @default.
• W2785181837 hasPublicationYear "2018" @default.
• W2785181837 type Work @default.
• W2785181837 sameAs 2785181837 @default.
• W2785181837 citedByCount "22" @default.
• W2785181837 countsByYear W27851818372018 @default.
• W2785181837 countsByYear W27851818372019 @default.
• W2785181837 countsByYear W27851818372020 @default.
• W2785181837 countsByYear W27851818372021 @default.
• W2785181837 countsByYear W27851818372022 @default.
• W2785181837 countsByYear W27851818372023 @default.
• W2785181837 crossrefType "journal-article" @default.
• W2785181837 hasAuthorship W2785181837A5002271830 @default.
• W2785181837 hasAuthorship W2785181837A5006117015 @default.
• W2785181837 hasAuthorship W2785181837A5014788936 @default.
• W2785181837 hasAuthorship W2785181837A5041325691 @default.
• W2785181837 hasAuthorship W2785181837A5045559519 @default.
• W2785181837 hasAuthorship W2785181837A5065970835 @default.
• W2785181837 hasAuthorship W2785181837A5082273690 @default.
• W2785181837 hasBestOaLocation W27851818371 @default.
• W2785181837 hasConcept C104317684 @default.
• W2785181837 hasConcept C113241181 @default.
• W2785181837 hasConcept C12554922 @default.
• W2785181837 hasConcept C155164980 @default.
• W2785181837 hasConcept C166342909 @default.
• W2785181837 hasConcept C170493617 @default.
• W2785181837 hasConcept C181199279 @default.
• W2785181837 hasConcept C182800266 @default.
• W2785181837 hasConcept C185592680 @default.
• W2785181837 hasConcept C194544171 @default.
• W2785181837 hasConcept C50254741 @default.
• W2785181837 hasConcept C55493867 @default.
• W2785181837 hasConcept C79879829 @default.

• next