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• W2785183658 abstract "Abstract 1,25-Dihydroxyvitamin D3 possesses therapeutic potential in numerous diseases such as cancer and osteoporosis but suffers from dose-limiting hypercalcemia, which has largely prevented its use in the clinic. Numerous studies have identified beneficial effects from the use of 1,25-dihydroxyvitamin D3 in combination with a second therapeutic agent, which may allow lower doses to be used. An alternative to standard combination therapy is the use of bifunctional molecules where a single species can modulate multiple targets simultaneously. In this review, we discuss the development of hybrids, which combine structural features of 1,25-dihydroxyvitamin D3 with those of several other molecule classes, notably histone deacetylase inhibitors, saponogens, and bisphosphonates, resulting in molecules with improved properties toward models of cancer, osteoporosis, and Alzheimer's disease." @default.
• W2785183658 created "2018-02-02" @default.
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• W2785183658 creator A5041687568 @default.
• W2785183658 date "2018-01-01" @default.
• W2785183658 modified "2023-09-26" @default.
• W2785183658 title "Bifunctional Vitamin D Hybrid Molecules" @default.
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• W2785183658 doi "https://doi.org/10.1016/b978-0-12-809963-6.00089-4" @default.
• W2785183658 hasPublicationYear "2018" @default.
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