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- W2785205640 abstract "通过全氟辛烷磺酸(PFOS) 28 d大鼠经口染毒评价PFOS肝损伤效应,探讨内质网应激在PFOS毒效应中的作用.Wistar大鼠随机分组,分别以0 mg· kg-1、5 mg·kg-1和10 mg·kg-1PFOS灌胃染毒28 d.HE染色观察大鼠肝脏形态改变.ELISA法测定各组丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)和淀粉酶(AMY)含量变化.紫外分光光度法测定肝组织匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性变化.RT-PCR检测肝脏内质网应激标志蛋白表达水平.结果表明,PFOS造成大鼠体重降低、肝重增高(P＜0.05),组织切片显示肝细胞出现脂质沉积.PFOS不同剂量组大鼠ALT随暴露浓度增加,分别为(50.96±10.02) U·L-1、(71.73±11.55) U· L-1,显著高于对照组(P＜0.05),AST、ALP含量与对照组相比显著上升(P＜0.05),高剂量组AMY水平为(833.46±63.05) U· L-1,与对照组相比显著降低(P＜0.05).GSH-Px和SOD水平随PFOS浓度增加出现了显著降低(P＜0.05),而MDA水平显著升高(P＜0.05).内质网应激标志蛋白表达均较对照组显著上升(P＜0.05).以上结果说明PFOS可导致大鼠肝细胞损伤,其机制可能与内质网应激调控有关." @default.
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- W2785205640 date "2016-01-01" @default.
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- W2785205640 title "Effects of Endoplasmic Reticulum Stress on Perfluorooctane Sulfonate Induced Liver Damage in Rat" @default.
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