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- W2785246265 endingPage "381" @default.
- W2785246265 startingPage "359" @default.
- W2785246265 abstract "IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of IgA in host-microbial mutualism has depended mainly on indirect evidence of alterations in microbiota composition or penetration of microbes in the absence of somatic mutations in IgA (or compensatory IgM). Highly parallel sequencing techniques that enable high-resolution analysis of either microbial consortia or IgA sequence diversity are now giving us new perspectives on selective targeting of microbial taxa and the trajectory of IgA diversification according to induction mechanisms, between different individuals and over time. The prospects are to link the range of diversified IgA clonotypes to specific antigenic functions in modulating the microbiota composition, position and metabolism to ensure host mutualism." @default.
- W2785246265 created "2018-02-02" @default.
- W2785246265 creator A5007532613 @default.
- W2785246265 creator A5018399191 @default.
- W2785246265 creator A5047340003 @default.
- W2785246265 creator A5091105548 @default.
- W2785246265 date "2018-04-26" @default.
- W2785246265 modified "2023-10-05" @default.
- W2785246265 title "IgA Function in Relation to the Intestinal Microbiota" @default.
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