Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785255303> ?p ?o ?g. }
- W2785255303 endingPage "317" @default.
- W2785255303 startingPage "305" @default.
- W2785255303 abstract "Serum antioxidants may afford neuroprotection against Alzheimer’s disease (AD) via correction of the pro-oxidative imbalance but findings reported have been inconsistent. We compared the pooled mean difference in serum levels of ten dietary antioxidants between patients with AD and cognitively inta ct controls from 52 studies in meta-analyses using random-effects models. Patients with AD had significantly lower plasma levels of α-carotene, β-carotene, lycopene, lutein, vitamin A, C, and E, and uric acid. No significant difference was observed for plasma levels of β-cryptoxanthin and zeaxanthin. Considerable heterogeneity was detected across studies. The lower serum levels of dietary antioxidants from the carotene and vitamin subclasses observed in individuals with AD suggest reduced systemic availability of these subclasses in this prevalent form of dementia. To our knowledge, these are the first meta-analyses to demonstrate lower serum lycopene and to evaluate β-cryptoxanthin, lutein, and zeaxanthin levels in AD. In light of the significant heterogeneity detected across studies, caution should be exercised in the interpretation of the data and therapeutic intervention approaches considered through supplementation measures. Our data may better inform interventions to improve antioxidant status in a condition of major public health importance." @default.
- W2785255303 created "2018-02-02" @default.
- W2785255303 creator A5020682446 @default.
- W2785255303 creator A5031466793 @default.
- W2785255303 creator A5044126197 @default.
- W2785255303 creator A5047639387 @default.
- W2785255303 creator A5050397593 @default.
- W2785255303 date "2018-02-06" @default.
- W2785255303 modified "2023-10-11" @default.
- W2785255303 title "Plasma Antioxidant Status in Patients with Alzheimer’s Disease and Cognitively Intact Elderly: A Meta-Analysis of Case-Control Studies" @default.
- W2785255303 cites W147719099 @default.
- W2785255303 cites W1498875382 @default.
- W2785255303 cites W1518741841 @default.
- W2785255303 cites W1567351354 @default.
- W2785255303 cites W1751439894 @default.
- W2785255303 cites W1904655223 @default.
- W2785255303 cites W1908751003 @default.
- W2785255303 cites W1920913771 @default.
- W2785255303 cites W1964550496 @default.
- W2785255303 cites W1965234101 @default.
- W2785255303 cites W1967203590 @default.
- W2785255303 cites W1969738113 @default.
- W2785255303 cites W1976792807 @default.
- W2785255303 cites W1981883193 @default.
- W2785255303 cites W1985969855 @default.
- W2785255303 cites W1989383588 @default.
- W2785255303 cites W1990493850 @default.
- W2785255303 cites W1990717594 @default.
- W2785255303 cites W1993383247 @default.
- W2785255303 cites W1994992483 @default.
- W2785255303 cites W2008822884 @default.
- W2785255303 cites W2016787732 @default.
- W2785255303 cites W2017076975 @default.
- W2785255303 cites W2018303090 @default.
- W2785255303 cites W2021041444 @default.
- W2785255303 cites W2021612723 @default.
- W2785255303 cites W2024037661 @default.
- W2785255303 cites W2028850203 @default.
- W2785255303 cites W2029925739 @default.
- W2785255303 cites W2032440627 @default.
- W2785255303 cites W2033898136 @default.
- W2785255303 cites W2037616683 @default.
- W2785255303 cites W2051143050 @default.
- W2785255303 cites W2053763036 @default.
- W2785255303 cites W2054021289 @default.
- W2785255303 cites W2058803950 @default.
- W2785255303 cites W2074707404 @default.
- W2785255303 cites W2077724894 @default.
- W2785255303 cites W2081216630 @default.
- W2785255303 cites W2083409755 @default.
- W2785255303 cites W2085385091 @default.
- W2785255303 cites W2088341782 @default.
- W2785255303 cites W2088790724 @default.
- W2785255303 cites W2090950309 @default.
- W2785255303 cites W2100283192 @default.
- W2785255303 cites W2107328434 @default.
- W2785255303 cites W2107820540 @default.
- W2785255303 cites W2112679668 @default.
- W2785255303 cites W2114725245 @default.
- W2785255303 cites W2128047032 @default.
- W2785255303 cites W2128634270 @default.
- W2785255303 cites W2128987869 @default.
- W2785255303 cites W2130940521 @default.
- W2785255303 cites W2135565955 @default.
- W2785255303 cites W2137769340 @default.
- W2785255303 cites W2138802159 @default.
- W2785255303 cites W2139931759 @default.
- W2785255303 cites W2149688229 @default.
- W2785255303 cites W2154813322 @default.
- W2785255303 cites W2156884900 @default.
- W2785255303 cites W2167564677 @default.
- W2785255303 cites W2233592504 @default.
- W2785255303 cites W2253446214 @default.
- W2785255303 cites W2338803032 @default.
- W2785255303 cites W2576440140 @default.
- W2785255303 cites W308892131 @default.
- W2785255303 cites W84838632 @default.
- W2785255303 doi "https://doi.org/10.3233/jad-170758" @default.
- W2785255303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29439339" @default.
- W2785255303 hasPublicationYear "2018" @default.
- W2785255303 type Work @default.
- W2785255303 sameAs 2785255303 @default.
- W2785255303 citedByCount "42" @default.
- W2785255303 countsByYear W27852553032018 @default.
- W2785255303 countsByYear W27852553032019 @default.
- W2785255303 countsByYear W27852553032020 @default.
- W2785255303 countsByYear W27852553032021 @default.
- W2785255303 countsByYear W27852553032022 @default.
- W2785255303 countsByYear W27852553032023 @default.
- W2785255303 crossrefType "journal-article" @default.
- W2785255303 hasAuthorship W2785255303A5020682446 @default.
- W2785255303 hasAuthorship W2785255303A5031466793 @default.
- W2785255303 hasAuthorship W2785255303A5044126197 @default.
- W2785255303 hasAuthorship W2785255303A5047639387 @default.
- W2785255303 hasAuthorship W2785255303A5050397593 @default.
- W2785255303 hasBestOaLocation W27852553032 @default.
- W2785255303 hasConcept C126322002 @default.
- W2785255303 hasConcept C134018914 @default.