FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785264295> ?p ?o ?g. }

• W2785264295 endingPage "22" @default.
• W2785264295 startingPage "22" @default.
• W2785264295 abstract "Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from our marine bacterial library. Twenty-one positive strains were screened out from 180 marine bacterial strains, and subsequent small-scale fermentation, HPLC and phylogenetic analysis afforded Bacillus sp. PKU-MA00092 and PKU-MA00093 as two candidates for large-scale fermentation and isolation. Ten nonribosomal peptides, including four bacillibactin analogues (1-4) and six bacillomycin D analogues (5-10) were discovered from Bacillus sp. PKU-MA00093 and PKU-MA00092, respectively. Compounds 1 and 2 are two new compounds and the ¹H NMR and 13C NMR data of compounds 7 and 9 is first provided. All compounds 1-10 were assayed for their cytotoxicities against human cancer cell lines HepG2 and MCF7, and the bacillomycin D analogues 7-10 showed moderate cytotoxicities with IC50 values from 2.9 ± 0.1 to 8.2 ± 0.2 µM. The discovery of 5-10 with different fatty acid moieties gave us the opportunity to reveal the structure-activity relationships of bacillomycin analogues against these human cancer cell lines. These results enrich the structural diversity and bioactivity properties of nonribosomal peptides from marine Bacillus strains." @default.
• W2785264295 created "2018-02-02" @default.
• W2785264295 creator A5000387903 @default.
• W2785264295 creator A5023630415 @default.
• W2785264295 creator A5032429023 @default.
• W2785264295 creator A5045292568 @default.
• W2785264295 creator A5048381562 @default.
• W2785264295 creator A5056036725 @default.
• W2785264295 creator A5067606563 @default.
• W2785264295 creator A5073778062 @default.
• W2785264295 creator A5080932631 @default.
• W2785264295 creator A5082156574 @default.
• W2785264295 date "2018-01-10" @default.
• W2785264295 modified "2023-10-06" @default.
• W2785264295 title "Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092" @default.
• W2785264295 cites W1022004273 @default.
• W2785264295 cites W116605652 @default.
• W2785264295 cites W1562683902 @default.
• W2785264295 cites W1936366167 @default.
• W2785264295 cites W1970386034 @default.
• W2785264295 cites W1973148544 @default.
• W2785264295 cites W1978189364 @default.
• W2785264295 cites W1979656224 @default.
• W2785264295 cites W1984165805 @default.
• W2785264295 cites W1985462529 @default.
• W2785264295 cites W1986839811 @default.
• W2785264295 cites W1998796156 @default.
• W2785264295 cites W2010106948 @default.
• W2785264295 cites W2016761967 @default.
• W2785264295 cites W2033578880 @default.
• W2785264295 cites W2038949613 @default.
• W2785264295 cites W2039835187 @default.
• W2785264295 cites W2052069581 @default.
• W2785264295 cites W2066477086 @default.
• W2785264295 cites W2067624527 @default.
• W2785264295 cites W2073491412 @default.
• W2785264295 cites W2087199904 @default.
• W2785264295 cites W2090695613 @default.
• W2785264295 cites W2091633829 @default.
• W2785264295 cites W2092746448 @default.
• W2785264295 cites W2099982193 @default.
• W2785264295 cites W2107639585 @default.
• W2785264295 cites W2117077410 @default.
• W2785264295 cites W2117495140 @default.
• W2785264295 cites W2117960631 @default.
• W2785264295 cites W2134573840 @default.
• W2785264295 cites W2140308749 @default.
• W2785264295 cites W2140855981 @default.
• W2785264295 cites W2146640936 @default.
• W2785264295 cites W2155687799 @default.
• W2785264295 cites W2159644566 @default.
• W2785264295 cites W2159923211 @default.
• W2785264295 cites W2197015970 @default.
• W2785264295 cites W2215306500 @default.
• W2785264295 cites W2235355521 @default.
• W2785264295 cites W2319108096 @default.
• W2785264295 cites W2321322765 @default.
• W2785264295 cites W2326842020 @default.
• W2785264295 cites W2624138918 @default.
• W2785264295 cites W2727144313 @default.
• W2785264295 cites W2950638012 @default.
• W2785264295 cites W2951482254 @default.
• W2785264295 cites W936159182 @default.
• W2785264295 doi "https://doi.org/10.3390/md16010022" @default.
• W2785264295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5793070" @default.
• W2785264295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29320403" @default.
• W2785264295 hasPublicationYear "2018" @default.
• W2785264295 type Work @default.
• W2785264295 sameAs 2785264295 @default.
• W2785264295 citedByCount "26" @default.
• W2785264295 countsByYear W27852642952018 @default.
• W2785264295 countsByYear W27852642952019 @default.
• W2785264295 countsByYear W27852642952020 @default.
• W2785264295 countsByYear W27852642952021 @default.
• W2785264295 countsByYear W27852642952022 @default.
• W2785264295 countsByYear W27852642952023 @default.
• W2785264295 crossrefType "journal-article" @default.
• W2785264295 hasAuthorship W2785264295A5000387903 @default.
• W2785264295 hasAuthorship W2785264295A5023630415 @default.
• W2785264295 hasAuthorship W2785264295A5032429023 @default.
• W2785264295 hasAuthorship W2785264295A5045292568 @default.
• W2785264295 hasAuthorship W2785264295A5048381562 @default.
• W2785264295 hasAuthorship W2785264295A5056036725 @default.
• W2785264295 hasAuthorship W2785264295A5067606563 @default.
• W2785264295 hasAuthorship W2785264295A5073778062 @default.
• W2785264295 hasAuthorship W2785264295A5080932631 @default.
• W2785264295 hasAuthorship W2785264295A5082156574 @default.
• W2785264295 hasBestOaLocation W27852642951 @default.
• W2785264295 hasConcept C100544194 @default.
• W2785264295 hasConcept C104317684 @default.
• W2785264295 hasConcept C185592680 @default.
• W2785264295 hasConcept C2777379556 @default.
• W2785264295 hasConcept C2779150676 @default.
• W2785264295 hasConcept C553450214 @default.
• W2785264295 hasConcept C55493867 @default.
• W2785264295 hasConcept C71240020 @default.
• W2785264295 hasConcept C86803240 @default.
• W2785264295 hasConcept C89423630 @default.

• next