FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785340070> ?p ?o ?g. }

• W2785340070 abstract "Familial partial lipodystrophy of the Dunnigan type is one of the most common inherited lipodystrophies variables. These individuals have important metabolic disorders that cause predisposition to various diseases. In this study we aimed to demonstrate the relation between the metabolic abnormalities, inflammatory profile and the expression of genes involved in the activation of the endoplasmic reticulum stress (ERS) in subjects with FPLD.We evaluated 14 female FPLD patients and compared with 13 female healthy individuals. The subjects were paired with their respective BMI and age and categorized into two groups: Familial partial lipodystrophy of the Dunnigan type (FPLD) and control. Patients were fasted for 12 h before blood collection for measurement of HbA1c, glucose, insulin, lipids and inflammatory markers. Subcutâneous adipose tissue was collected by puncture aspiration of submental region during ambulatorial surgical aesthetic procedure.We demonstrate that patients with FPLD show increased HbA1c (p < 0.01), fasting glucose (p < 0.002) and triglycerides (p < 0.005) while HDL/cholesterol (p < 0.001) was lower when compared to healthy individuals. We found that 64.2% FPLD patients had metabolic syndrome according to International Diabetes Federation definition. We also observe increased AUC of glucose (p < 0.001) and insulin during oGTT, featuring a frame of hyperglycemia and hyperinsulinemia, suggesting insulin resistance. Also we found hyperactivation of several genes responsible for ERS such as ATF-4 (p < 0.01), ATF-6 (p < 0.01), EIF2α3K (p < 0.005), CCT4 (p < 0.001), CHOP (p < 0.01), CALR (p < 0.001) and CANX (p < 0.005), that corroborate the idea that diabetes mellitus and metabolic syndrome are associated with direct damage to the endoplasmic reticulum homeostasis. Ultimately, we note that individuals with lipodystrophy have an increase in serum interleukins, keys of the inflammatory process, as IL-1β, TNF-α and IL-6 (p < 0.05 all), compared with healthy individuals, which can be the trigger to insulin resistance in this population.Individuals with FPLD besides having typical dysfunctions of metabolic syndrome, show a hyperactivation of ERS associated with increased systemic inflammatory profile, which together may explain the complex clinical aspect of this diseases.Trial registration HCRP no 6711/2012." @default.
• W2785340070 created "2018-02-23" @default.
• W2785340070 creator A5025164366 @default.
• W2785340070 creator A5034244660 @default.
• W2785340070 creator A5039463155 @default.
• W2785340070 creator A5059282427 @default.
• W2785340070 creator A5063851771 @default.
• W2785340070 creator A5088961403 @default.
• W2785340070 creator A5091502845 @default.
• W2785340070 date "2018-02-09" @default.
• W2785340070 modified "2023-10-17" @default.
• W2785340070 title "Endoplasmic reticulum stress activation in adipose tissue induces metabolic syndrome in individuals with familial partial lipodystrophy of the Dunnigan type" @default.
• W2785340070 cites W1657819900 @default.
• W2785340070 cites W1675830194 @default.
• W2785340070 cites W1971762417 @default.
• W2785340070 cites W1979354059 @default.
• W2785340070 cites W1982471816 @default.
• W2785340070 cites W1982709555 @default.
• W2785340070 cites W1985649195 @default.
• W2785340070 cites W1994109058 @default.
• W2785340070 cites W1994174603 @default.
• W2785340070 cites W1999032458 @default.
• W2785340070 cites W2007078899 @default.
• W2785340070 cites W2009330135 @default.
• W2785340070 cites W2011580184 @default.
• W2785340070 cites W2027604252 @default.
• W2785340070 cites W2029541656 @default.
• W2785340070 cites W2029642537 @default.
• W2785340070 cites W2030501120 @default.
• W2785340070 cites W2042117981 @default.
• W2785340070 cites W2046006262 @default.
• W2785340070 cites W2047201865 @default.
• W2785340070 cites W2057983275 @default.
• W2785340070 cites W2062438372 @default.
• W2785340070 cites W2074245449 @default.
• W2785340070 cites W2075183868 @default.
• W2785340070 cites W2080359869 @default.
• W2785340070 cites W2081210006 @default.
• W2785340070 cites W2086501247 @default.
• W2785340070 cites W2093510590 @default.
• W2785340070 cites W2107601804 @default.
• W2785340070 cites W2114757487 @default.
• W2785340070 cites W2119902047 @default.
• W2785340070 cites W2124368774 @default.
• W2785340070 cites W2129316761 @default.
• W2785340070 cites W2134791224 @default.
• W2785340070 cites W2138009056 @default.
• W2785340070 cites W2152377123 @default.
• W2785340070 cites W2153050742 @default.
• W2785340070 cites W2153574614 @default.
• W2785340070 cites W2159898699 @default.
• W2785340070 cites W2160234571 @default.
• W2785340070 cites W2161681574 @default.
• W2785340070 cites W2607031541 @default.
• W2785340070 cites W2740055330 @default.
• W2785340070 cites W4248136323 @default.
• W2785340070 doi "https://doi.org/10.1186/s13098-017-0301-6" @default.
• W2785340070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5807843" @default.
• W2785340070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29449893" @default.
• W2785340070 hasPublicationYear "2018" @default.
• W2785340070 type Work @default.
• W2785340070 sameAs 2785340070 @default.
• W2785340070 citedByCount "9" @default.
• W2785340070 countsByYear W27853400702019 @default.
• W2785340070 countsByYear W27853400702021 @default.
• W2785340070 countsByYear W27853400702023 @default.
• W2785340070 crossrefType "journal-article" @default.
• W2785340070 hasAuthorship W2785340070A5025164366 @default.
• W2785340070 hasAuthorship W2785340070A5034244660 @default.
• W2785340070 hasAuthorship W2785340070A5039463155 @default.
• W2785340070 hasAuthorship W2785340070A5059282427 @default.
• W2785340070 hasAuthorship W2785340070A5063851771 @default.
• W2785340070 hasAuthorship W2785340070A5088961403 @default.
• W2785340070 hasAuthorship W2785340070A5091502845 @default.
• W2785340070 hasBestOaLocation W27853400701 @default.
• W2785340070 hasConcept C126322002 @default.
• W2785340070 hasConcept C134018914 @default.
• W2785340070 hasConcept C142462285 @default.
• W2785340070 hasConcept C158617107 @default.
• W2785340070 hasConcept C171089720 @default.
• W2785340070 hasConcept C203014093 @default.
• W2785340070 hasConcept C2777180221 @default.
• W2785340070 hasConcept C2777391703 @default.
• W2785340070 hasConcept C2779306644 @default.
• W2785340070 hasConcept C2780578515 @default.
• W2785340070 hasConcept C2780941825 @default.
• W2785340070 hasConcept C2780988686 @default.
• W2785340070 hasConcept C2993143319 @default.
• W2785340070 hasConcept C3013748606 @default.
• W2785340070 hasConcept C54355233 @default.
• W2785340070 hasConcept C555293320 @default.
• W2785340070 hasConcept C71924100 @default.
• W2785340070 hasConcept C86803240 @default.
• W2785340070 hasConceptScore W2785340070C126322002 @default.
• W2785340070 hasConceptScore W2785340070C134018914 @default.
• W2785340070 hasConceptScore W2785340070C142462285 @default.
• W2785340070 hasConceptScore W2785340070C158617107 @default.
• W2785340070 hasConceptScore W2785340070C171089720 @default.
• W2785340070 hasConceptScore W2785340070C203014093 @default.
• W2785340070 hasConceptScore W2785340070C2777180221 @default.

• next