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• W2785341402 abstract "OBJECTIVE OF THE STUDY: The problem of urinary stone or calculi is a very ancient one . The stones form in all parts ofthe urinary tract , the kidneys, the ureters and in bladders and they may vary in sizeconsiderably .Majority of calculi are made up of Calcium oxalate, calcium phosphate, uric acid ormagnesium ammonium phosphate. In India the common components of urinary calculi iscalcium oxalate. A number of vegetable drugs have been used in India and elsewhereand gainefficient cure of urinary stones58.There are several options available in the management of ureteral stones. Treatment dependsupon the size of the stones, composition and associated morbidity, physician skill, patienthealth ,preference and finally costs Many remedies have been employed during the ages for treating urolithiasis. Most of theremedies were taken from plants proved to be useful, though the rational behind their use isnot scientifically established except for a few plants and some proprietary composite herbaldrugs. SUMMARY AND CONCLUSION:Urolithiasis is one of the most painful urological disorder when compared to the otherpainful disorders. Kidney stone disease has afflicted human kind since antiquity and canpersist, with serious medical consequences, throughout a patient’s life time. In addition, theincidence of kidney stones has been increased in most societies in the last five decades,especially in association with economic development. In spite of tremendous advances in thefield of medicine, there is truly no satisfactory drug for the treatment of nephrolithiasis.Recently, there is increasing evidence that many healthy natural food and medicinalherbal and supplements have the potential to become valuable complementary therapy in thetreatment of various renal disorders and in the protection against nephrotoxicity.The plant Apium graveolens is traditionally used for in different disorders such asanti-inflammatory activity, anticancer, antidiabetic, , hepatoprotective activity, etc.. Anattempt was made to study urolithiatic activity in ethylene glycol and ammonium chlorideinduced method.The preliminary phytochemical analysis of EEAG showed the presence of alkaloids,carbohydrates, cardiac glycoside, sterols & saponins, tannins, flavonoids are used againsturolithiasis.The anti-urolithiasis activity of Apium graveolens seeds is may be due to the presenceof flavonoids and tanins.Animals were divided in to 5 groups . Group I-Control, Group II-Negative control,Group III-Treated with standard drug, Group IV-Treated with Lower dose , Group-IVTreatedwith higher dose. Data comparison was made between Group I – Group V.Urolithiasis was induced by feeding Ethylene glycol with ammonium chloride for 28 days.Statistical significance was done by ANOVA , followed by Dunnett’s multiple comparisontestCaOx and CaP deposition in the kidneys of EG and ammonium chloride fed animals .Treatment with EEAG (200/400 mg/kg) for 14 days successfully prevented theelevation of deposition of CaOx , phosphate in kidney when compared to the standarddrug.Significant decrease in Body weight, Feed intake, water intake observed in EG fedanimals . Treatment with EEAG (200/400 mg/kg) for 14 days successfully increasesthe Body weight, water intake and food intake , when compared to the standard drug. Increased urinary excretion of urinary calcium , oxalate, and phosphate are observedin EG and ammonium chloride fed animals . Treatment with EEAG (200/400 mg/kg)for 14 days successfully decreased the excretion of oxalate, calcium, phosphate whencompared to the standard drug.Serum creatinine , uric acid, Urea increased in EG and ammonium chloride fedanimals due to decreased GFR. Treatment with EEAG (200/400 mg/kg) for 14 dayssuccessfully decreases the serum creatinine, uric acid, Urea when compared tostandard drug.Histo pathological findings of the EG fed animals are distended tubules, dilation anddeposition of crystals. The histopathology of kidney was brought to normal in EEAGtreated animals when compared to the standard drug.The present study indicates that the administration of EEAG to rats in ethylene glycoland ammonium chloride induced urolithiasis reduces the growth and development of kidneystones by reducing the stone forming constituents by increasing the GFR . Accordingly, it canbe concluded that the supplementation of Apium graveoelns has a beneficial effect onurolithiasis .Further studies are needed to identify the molecular mechanism of Apium graveoelnsand the structural elucidation of phytoconstituents responsible for antiurolithiasis" @default.
• W2785341402 created "2018-02-23" @default.
• W2785341402 creator A5087281049 @default.
• W2785341402 date "2017-10-01" @default.
• W2785341402 modified "2023-09-27" @default.
• W2785341402 title "Evaluation of Anti Nephrolithiatic Activity of Ethanolic Extract of Apium Graveolens Seeds on Ethylene Glycol and Ammonium Chloride Induced Urolithiasis in Male Wistar Albino Rats" @default.
• W2785341402 hasPublicationYear "2017" @default.
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