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• W2785393677 endingPage "234" @default.
• W2785393677 startingPage "229" @default.
• W2785393677 abstract "Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation). Therefore, modulating Nrf2 can be a new therapeutic approach to reduce inflammation and oxidative stress in CKD. Low-protein diet (LPD) prescribed for nondialysis CKD patients presents numerous benefits already well established, including reduction of inflammation and oxidative stress. However, there is no available data regarding the relationship between LPD and Nrf2 modulation in these patients. This review aims to discuss the impact, if any, of LPD on Nrf2 expression, in nondialysis CKD patients. Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation). Therefore, modulating Nrf2 can be a new therapeutic approach to reduce inflammation and oxidative stress in CKD. Low-protein diet (LPD) prescribed for nondialysis CKD patients presents numerous benefits already well established, including reduction of inflammation and oxidative stress. However, there is no available data regarding the relationship between LPD and Nrf2 modulation in these patients. This review aims to discuss the impact, if any, of LPD on Nrf2 expression, in nondialysis CKD patients." @default.
• W2785393677 created "2018-02-23" @default.
• W2785393677 creator A5001567431 @default.
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• W2785393677 creator A5036474175 @default.
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• W2785393677 creator A5045817626 @default.
• W2785393677 date "2018-07-01" @default.
• W2785393677 modified "2023-09-30" @default.
• W2785393677 title "Could Low-Protein Diet Modulate Nrf2 Pathway in Chronic Kidney Disease?" @default.
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• W2785393677 doi "https://doi.org/10.1053/j.jrn.2017.11.005" @default.
• W2785393677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29452888" @default.
• W2785393677 hasPublicationYear "2018" @default.
• W2785393677 type Work @default.

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