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- W2785404011 endingPage "120" @default.
- W2785404011 startingPage "120" @default.
- W2785404011 abstract "Hypertension is asymptomatic and a well-known silent killer, which can cause various concomitant diseases in human population after years of adherence. Although there are varieties of synthetic antihypertensive drugs available in current market, their relatively low efficacies and major application in only single drug therapy, as well as the undesired chronic adverse effects associated, has drawn the attention of worldwide scientists. According to the trend of antihypertensive drug evolution, the antihypertensive drugs used as primary treatment often change from time-to-time with the purpose of achieving the targeted blood pressure range. One of the major concerns that need to be accounted for here is that the signaling mechanism pathways involved in the vasculature during the vascular tone regulation should be clearly understood during the pharmacological research of antihypertensive drugs, either in vitro or in vivo. There are plenty of articles that discussed the signaling mechanism pathways mediated in vascular tone in isolated fragments instead of a whole comprehensive image. Therefore, the present review aims to summarize previous published vasculature-related studies and provide an overall depiction of each pathway including endothelium-derived relaxing factors, G-protein-coupled, enzyme-linked, and channel-linked receptors that occurred in the microenvironment of vasculature with a full schematic diagram on the ways their signals interact. Furthermore, the crucial vasodilative receptors that should be included in the mechanisms of actions study on vasodilatory effects of test compounds were suggested in the present review as well." @default.
- W2785404011 created "2018-02-23" @default.
- W2785404011 creator A5014905058 @default.
- W2785404011 creator A5022342674 @default.
- W2785404011 creator A5023856548 @default.
- W2785404011 creator A5073476874 @default.
- W2785404011 creator A5081495391 @default.
- W2785404011 date "2018-01-02" @default.
- W2785404011 modified "2023-10-05" @default.
- W2785404011 title "Overview of the Microenvironment of Vasculature in Vascular Tone Regulation" @default.
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- W2785404011 doi "https://doi.org/10.3390/ijms19010120" @default.
- W2785404011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5796069" @default.
- W2785404011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29301280" @default.
- W2785404011 hasPublicationYear "2018" @default.