FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785407317> ?p ?o ?g. }

• W2785407317 endingPage "14938" @default.
• W2785407317 startingPage "14922" @default.
• W2785407317 abstract "The extent of resistance to immune surveillance in patients with well-differentiated (Wd) (grade 1/2) small-intestinal neuroendocrine tumours (Si-NETs) is unknown.Patients diagnosed with Wd Si-NETs (excluding appendix, which are considered to have a different biology to other midgut NETs) were eligible. Tumoural programmed death (PD)-ligand(L) 1 (PD-L1)/PD-L2/PD-1 and tumour infiltrating lymphocytes (TILs) [presence and phenotype] were analysed in archival tissue by immunohistochemistry (IHC); reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used for confirmation of IHC results.Of 109 patients screened, 62 were eligible: 54.8% were male; median age was 63.7 years (95%-CI 59.7-67.2); disease stage II: 4.8%, III: 40.3% and IV: 54.8%; 41.9% were functional. Analysed samples (67.1% from primary tumours, 32.9% from metastases) were of grade 1 (67.1%) or 2 (32.86%) with a median Ki-67 of 2%. From the total of 62 eligible patients, 70 and 63 samples were suitable for IHC and RT-qPCR analysis, respectively. PD-L1 expression within tumour cells and TILs were identified in 12.8% and 24.3% of samples respectively; 30% of samples showed PD-L1 expression within tumour cells and/or TILs. PD-1 was present in TILs in 22.8% of samples. Majority of samples showed significant presence of CD4+ (focal 42.86%; moderate 2.86%) and CD8+ (focal 92.86%; moderate 4.29%) TILs. IHC findings were confirmed with RT-qPCR; which showed higher expression levels of PD-L1 (p-value 0.007) and PD-1 (p-value 0.001) in samples positive for IHC compared to negative-IHC.Thirty-percent of patients express PD-L1 within tumour cells and/or TILs. Identification of presence of TILs was also significant and warrant the investigation of immunotherapy in this setting." @default.
• W2785407317 created "2018-02-23" @default.
• W2785407317 creator A5017833052 @default.
• W2785407317 creator A5025528747 @default.
• W2785407317 creator A5027955740 @default.
• W2785407317 creator A5030184193 @default.
• W2785407317 creator A5041768679 @default.
• W2785407317 creator A5046694373 @default.
• W2785407317 creator A5060729173 @default.
• W2785407317 creator A5074217604 @default.
• W2785407317 creator A5075059160 @default.
• W2785407317 creator A5077826150 @default.
• W2785407317 creator A5078388816 @default.
• W2785407317 creator A5087850177 @default.
• W2785407317 creator A5090864400 @default.
• W2785407317 date "2018-02-12" @default.
• W2785407317 modified "2023-10-12" @default.
• W2785407317 title "PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours" @default.
• W2785407317 cites W1809627231 @default.
• W2785407317 cites W1889335134 @default.
• W2785407317 cites W1896688767 @default.
• W2785407317 cites W1940241680 @default.
• W2785407317 cites W1949964307 @default.
• W2785407317 cites W1964030431 @default.
• W2785407317 cites W1980825355 @default.
• W2785407317 cites W1982488143 @default.
• W2785407317 cites W1990675339 @default.
• W2785407317 cites W1991912136 @default.
• W2785407317 cites W1995593462 @default.
• W2785407317 cites W2010121426 @default.
• W2785407317 cites W2016983859 @default.
• W2785407317 cites W2019607817 @default.
• W2785407317 cites W2021382013 @default.
• W2785407317 cites W2043115278 @default.
• W2785407317 cites W2063264144 @default.
• W2785407317 cites W2063886011 @default.
• W2785407317 cites W2082118645 @default.
• W2785407317 cites W2085299433 @default.
• W2785407317 cites W2086074184 @default.
• W2785407317 cites W2093326954 @default.
• W2785407317 cites W2094723762 @default.
• W2785407317 cites W2096322385 @default.
• W2785407317 cites W2100283328 @default.
• W2785407317 cites W2108604103 @default.
• W2785407317 cites W2109485845 @default.
• W2785407317 cites W2112434826 @default.
• W2785407317 cites W2113557272 @default.
• W2785407317 cites W2117692326 @default.
• W2785407317 cites W2125522413 @default.
• W2785407317 cites W2135049144 @default.
• W2785407317 cites W2137142564 @default.
• W2785407317 cites W2137297087 @default.
• W2785407317 cites W2149214723 @default.
• W2785407317 cites W2150048477 @default.
• W2785407317 cites W2152061559 @default.
• W2785407317 cites W2152897456 @default.
• W2785407317 cites W2160834915 @default.
• W2785407317 cites W2164842455 @default.
• W2785407317 cites W2166417489 @default.
• W2785407317 cites W2198093519 @default.
• W2785407317 cites W2209368665 @default.
• W2785407317 cites W2251552985 @default.
• W2785407317 cites W2278280755 @default.
• W2785407317 cites W2291789139 @default.
• W2785407317 cites W2296064806 @default.
• W2785407317 cites W2331204701 @default.
• W2785407317 cites W2337659275 @default.
• W2785407317 cites W2338576144 @default.
• W2785407317 cites W2339890238 @default.
• W2785407317 cites W2365348826 @default.
• W2785407317 cites W2400328547 @default.
• W2785407317 cites W2401455386 @default.
• W2785407317 cites W2482010 @default.
• W2785407317 cites W2495896890 @default.
• W2785407317 cites W2509915127 @default.
• W2785407317 cites W2510686645 @default.
• W2785407317 cites W2523194272 @default.
• W2785407317 cites W2527905628 @default.
• W2785407317 cites W2529588573 @default.
• W2785407317 cites W2560367415 @default.
• W2785407317 cites W2572174216 @default.
• W2785407317 cites W2573369749 @default.
• W2785407317 cites W2574604975 @default.
• W2785407317 cites W2763770778 @default.
• W2785407317 cites W2766903152 @default.
• W2785407317 cites W2774520615 @default.
• W2785407317 doi "https://doi.org/10.18632/oncotarget.24464" @default.
• W2785407317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5871087" @default.
• W2785407317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29599916" @default.
• W2785407317 hasPublicationYear "2018" @default.
• W2785407317 type Work @default.
• W2785407317 sameAs 2785407317 @default.
• W2785407317 citedByCount "28" @default.
• W2785407317 countsByYear W27854073172018 @default.
• W2785407317 countsByYear W27854073172019 @default.
• W2785407317 countsByYear W27854073172020 @default.
• W2785407317 countsByYear W27854073172021 @default.
• W2785407317 countsByYear W27854073172022 @default.

• next