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- W2785443776 abstract "Regulatory variants are often context specific, modulating gene expression in a subset of possible cellular states. Although these genetic effects can play important roles in disease, the molecular mechanisms underlying context specificity are poorly understood. Here, we identified shared quantitative trait loci (QTLs) for chromatin accessibility and gene expression in human macrophages exposed to IFNγ, Salmonella and IFNγ plus Salmonella. We observed that ~60% of stimulus-specific expression QTLs with a detectable effect on chromatin altered the chromatin accessibility in naive cells, thus suggesting that they perturb enhancer priming. Such variants probably influence binding of cell-type-specific transcription factors, such as PU.1, which can then indirectly alter the binding of stimulus-specific transcription factors, such as NF-κB or STAT2. Thus, although chromatin accessibility assays are powerful for fine-mapping causal regulatory variants, detecting their downstream effects on gene expression will be challenging, requiring profiling of large numbers of stimulated cellular states and time points." @default.
- W2785443776 created "2018-02-23" @default.
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- W2785443776 date "2018-01-29" @default.
- W2785443776 modified "2023-10-09" @default.
- W2785443776 title "Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response" @default.
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- W2785443776 cites W2018439988 @default.
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- W2785443776 cites W2033202128 @default.
- W2785443776 cites W2037299986 @default.
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- W2785443776 doi "https://doi.org/10.1038/s41588-018-0046-7" @default.
- W2785443776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548559" @default.
- W2785443776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29379200" @default.
- W2785443776 hasPublicationYear "2018" @default.
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