FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785475598> ?p ?o ?g. }

• W2785475598 endingPage "792" @default.
• W2785475598 startingPage "782" @default.
• W2785475598 abstract "Sirtuins consume stoichiometric amounts of nicotinamide adenine dinucleotide (NAD+) to remove an acetyl group from lysine residues. These enzymes have been implicated in regulating various cellular events and have also been suggested to mediate the beneficial effects of calorie restriction (CR). However, controversies on sirtuin biology also peaked during the past few years because of conflicting results from different research groups. This is partly because these enzymes have been discovered recently and the intricate interaction loops between sirtuins and other proteins make the characterization of them extremely difficult. Current molecular biology and proteomics techniques report protein abundance rather than active sirtuin content. Innovative chemical tools that can directly probe the functional state of sirtuins are desperately needed. We have obtained a set of powerful activity-based chemical probes that are capable of assessing the active content of sirtuins in model systems. These probes consist of a chemical warhead that binds to the active site of active enzyme and a handle that can be used for the visualization of these enzymes by fluorescence. In complex native proteome, the probes can selectively highlight the active sirtuin components. Furthermore, these probes were also able to probe the dynamic change of sirtuin activity in response to cellular stimuli. These chemical probes and the labeling strategies will provide transformative technology to allow the direct linking of sirtuin activity to distinct physiological processes. They will create new opportunities to investigate how sirtuins provide health benefits in adapting cells to environmental cues and provide critical information to dissect sirtuin regulatory networks." @default.
• W2785475598 created "2018-02-23" @default.
• W2785475598 creator A5033182905 @default.
• W2785475598 creator A5035403797 @default.
• W2785475598 creator A5041202739 @default.
• W2785475598 creator A5091583160 @default.
• W2785475598 date "2018-01-31" @default.
• W2785475598 modified "2023-10-17" @default.
• W2785475598 title "Development of Activity-Based Chemical Probes for Human Sirtuins" @default.
• W2785475598 cites W1965488403 @default.
• W2785475598 cites W1968222033 @default.
• W2785475598 cites W1969269167 @default.
• W2785475598 cites W1972924731 @default.
• W2785475598 cites W1974077150 @default.
• W2785475598 cites W1975397970 @default.
• W2785475598 cites W1978702638 @default.
• W2785475598 cites W1981194888 @default.
• W2785475598 cites W1981549228 @default.
• W2785475598 cites W1982517443 @default.
• W2785475598 cites W1984658022 @default.
• W2785475598 cites W1985308585 @default.
• W2785475598 cites W1986511022 @default.
• W2785475598 cites W1987178054 @default.
• W2785475598 cites W1990022835 @default.
• W2785475598 cites W1992913613 @default.
• W2785475598 cites W2003155232 @default.
• W2785475598 cites W2007842741 @default.
• W2785475598 cites W2007936205 @default.
• W2785475598 cites W2018161655 @default.
• W2785475598 cites W2020304127 @default.
• W2785475598 cites W2022767678 @default.
• W2785475598 cites W2023674187 @default.
• W2785475598 cites W2024551271 @default.
• W2785475598 cites W2031594453 @default.
• W2785475598 cites W2032653170 @default.
• W2785475598 cites W2046370400 @default.
• W2785475598 cites W2048233599 @default.
• W2785475598 cites W2049691986 @default.
• W2785475598 cites W2053213876 @default.
• W2785475598 cites W2059267070 @default.
• W2785475598 cites W2061576857 @default.
• W2785475598 cites W2061742768 @default.
• W2785475598 cites W2062220403 @default.
• W2785475598 cites W2063113940 @default.
• W2785475598 cites W2064352591 @default.
• W2785475598 cites W2074740541 @default.
• W2785475598 cites W2076739074 @default.
• W2785475598 cites W2078015793 @default.
• W2785475598 cites W2082393205 @default.
• W2785475598 cites W2086102706 @default.
• W2785475598 cites W2086201463 @default.
• W2785475598 cites W2087497962 @default.
• W2785475598 cites W2088375253 @default.
• W2785475598 cites W2088381487 @default.
• W2785475598 cites W2088511656 @default.
• W2785475598 cites W2090897179 @default.
• W2785475598 cites W2092160215 @default.
• W2785475598 cites W2102646072 @default.
• W2785475598 cites W2103416697 @default.
• W2785475598 cites W2106715610 @default.
• W2785475598 cites W2110271190 @default.
• W2785475598 cites W2112275733 @default.
• W2785475598 cites W2115217941 @default.
• W2785475598 cites W2118964113 @default.
• W2785475598 cites W2125810574 @default.
• W2785475598 cites W2134297481 @default.
• W2785475598 cites W2136829516 @default.
• W2785475598 cites W2138499549 @default.
• W2785475598 cites W2148029256 @default.
• W2785475598 cites W2152390180 @default.
• W2785475598 cites W2158092222 @default.
• W2785475598 cites W2159229473 @default.
• W2785475598 cites W2160600666 @default.
• W2785475598 cites W2169880855 @default.
• W2785475598 cites W2177552052 @default.
• W2785475598 cites W2399119114 @default.
• W2785475598 cites W2535718125 @default.
• W2785475598 cites W2621737540 @default.
• W2785475598 cites W2745522568 @default.
• W2785475598 doi "https://doi.org/10.1021/acschembio.7b00754" @default.
• W2785475598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5889851" @default.
• W2785475598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29385333" @default.
• W2785475598 hasPublicationYear "2018" @default.
• W2785475598 type Work @default.
• W2785475598 sameAs 2785475598 @default.
• W2785475598 citedByCount "20" @default.
• W2785475598 countsByYear W27854755982018 @default.
• W2785475598 countsByYear W27854755982020 @default.
• W2785475598 countsByYear W27854755982021 @default.
• W2785475598 countsByYear W27854755982022 @default.
• W2785475598 countsByYear W27854755982023 @default.
• W2785475598 crossrefType "journal-article" @default.
• W2785475598 hasAuthorship W2785475598A5033182905 @default.
• W2785475598 hasAuthorship W2785475598A5035403797 @default.
• W2785475598 hasAuthorship W2785475598A5041202739 @default.
• W2785475598 hasAuthorship W2785475598A5091583160 @default.
• W2785475598 hasBestOaLocation W27854755982 @default.
• W2785475598 hasConcept C104317684 @default.

• next