FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785484560> ?p ?o ?g. }

• W2785484560 endingPage "492" @default.
• W2785484560 startingPage "481" @default.
• W2785484560 abstract "Glioblastoma is a highly malignant disease in critical need of expanded treatment options. The AURKA inhibitor alisertib exhibits antiproliferative activity against glioblastoma in vitro and in vivo. Unlike current clinically used taxane drugs, the novel taxane TPI 287 penetrates the CNS. We tested for interactions between three selective AURKA inhibitors and TPI 287 against standard U87 and U1242 cells and primary glioblastoma neurospheres using colony formation assays. Bliss and Chou–Talalay analyses were utilized to statistically test for synergism. Morphological analysis, flow cytometry and annexin V binding were employed to examine cell cycle and apoptotic effects of these drug combinations. TPI 287 not only potentiated the cytotoxicity of the AURKA inhibitors alisertib, MLN8054 and TC-A2317, but was often potently synergistic. Morphologic and biochemical analysis of the combined effects of alisertib and TPI 287 consistently revealed synergistic induction of apoptosis. While each agent alone induces a mitotic block, slippage occurs allowing some tumor cells to avoid apoptosis. Combination treatment greatly attenuated mitotic slippage, committing the majority of cells to apoptosis. Alisertib and TPI 287 demonstrate significant synergism against glioblastoma cells largely attributable to a synergistic effect in inducing apoptosis. These results provide compelling rationale for clinical testing of alisertib and/or other AURKA inhibitors for potential combination use with TPI 287 against glioblastoma and other CNS neoplasms." @default.
• W2785484560 created "2018-02-23" @default.
• W2785484560 creator A5002054688 @default.
• W2785484560 creator A5013697180 @default.
• W2785484560 creator A5019462765 @default.
• W2785484560 creator A5032801026 @default.
• W2785484560 creator A5034723009 @default.
• W2785484560 creator A5039736288 @default.
• W2785484560 creator A5041195613 @default.
• W2785484560 creator A5044346370 @default.
• W2785484560 creator A5058082845 @default.
• W2785484560 creator A5061957201 @default.
• W2785484560 creator A5072256090 @default.
• W2785484560 creator A5078138155 @default.
• W2785484560 date "2018-02-02" @default.
• W2785484560 modified "2023-10-14" @default.
• W2785484560 title "The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells" @default.
• W2785484560 cites W1578932543 @default.
• W2785484560 cites W1616592835 @default.
• W2785484560 cites W1906424257 @default.
• W2785484560 cites W1958838451 @default.
• W2785484560 cites W1964317189 @default.
• W2785484560 cites W1971896486 @default.
• W2785484560 cites W1976033985 @default.
• W2785484560 cites W1981073960 @default.
• W2785484560 cites W1982626083 @default.
• W2785484560 cites W1985338536 @default.
• W2785484560 cites W1987616570 @default.
• W2785484560 cites W1998353633 @default.
• W2785484560 cites W2008769862 @default.
• W2785484560 cites W2027740621 @default.
• W2785484560 cites W2044614871 @default.
• W2785484560 cites W2046929013 @default.
• W2785484560 cites W2051171632 @default.
• W2785484560 cites W2060737851 @default.
• W2785484560 cites W2063770164 @default.
• W2785484560 cites W2064261028 @default.
• W2785484560 cites W2071788428 @default.
• W2785484560 cites W2077945404 @default.
• W2785484560 cites W2090145833 @default.
• W2785484560 cites W2097010776 @default.
• W2785484560 cites W2098801882 @default.
• W2785484560 cites W2128978033 @default.
• W2785484560 cites W2135709083 @default.
• W2785484560 cites W2153081604 @default.
• W2785484560 cites W2154094988 @default.
• W2785484560 cites W2162262059 @default.
• W2785484560 cites W2171734408 @default.
• W2785484560 cites W2223501982 @default.
• W2785484560 cites W2295308497 @default.
• W2785484560 cites W2335854816 @default.
• W2785484560 cites W2397161433 @default.
• W2785484560 cites W2592682092 @default.
• W2785484560 doi "https://doi.org/10.1007/s11060-018-2755-2" @default.
• W2785484560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6097628" @default.
• W2785484560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29396807" @default.
• W2785484560 hasPublicationYear "2018" @default.
• W2785484560 type Work @default.
• W2785484560 sameAs 2785484560 @default.
• W2785484560 citedByCount "14" @default.
• W2785484560 countsByYear W27854845602019 @default.
• W2785484560 countsByYear W27854845602020 @default.
• W2785484560 countsByYear W27854845602021 @default.
• W2785484560 countsByYear W27854845602022 @default.
• W2785484560 countsByYear W27854845602023 @default.
• W2785484560 crossrefType "journal-article" @default.
• W2785484560 hasAuthorship W2785484560A5002054688 @default.
• W2785484560 hasAuthorship W2785484560A5013697180 @default.
• W2785484560 hasAuthorship W2785484560A5019462765 @default.
• W2785484560 hasAuthorship W2785484560A5032801026 @default.
• W2785484560 hasAuthorship W2785484560A5034723009 @default.
• W2785484560 hasAuthorship W2785484560A5039736288 @default.
• W2785484560 hasAuthorship W2785484560A5041195613 @default.
• W2785484560 hasAuthorship W2785484560A5044346370 @default.
• W2785484560 hasAuthorship W2785484560A5058082845 @default.
• W2785484560 hasAuthorship W2785484560A5061957201 @default.
• W2785484560 hasAuthorship W2785484560A5072256090 @default.
• W2785484560 hasAuthorship W2785484560A5078138155 @default.
• W2785484560 hasBestOaLocation W27854845602 @default.
• W2785484560 hasConcept C121608353 @default.
• W2785484560 hasConcept C185592680 @default.
• W2785484560 hasConcept C190283241 @default.
• W2785484560 hasConcept C203014093 @default.
• W2785484560 hasConcept C2777511904 @default.
• W2785484560 hasConcept C502942594 @default.
• W2785484560 hasConcept C530470458 @default.
• W2785484560 hasConcept C54355233 @default.
• W2785484560 hasConcept C553184892 @default.
• W2785484560 hasConcept C55493867 @default.
• W2785484560 hasConcept C86803240 @default.
• W2785484560 hasConcept C88634738 @default.
• W2785484560 hasConceptScore W2785484560C121608353 @default.
• W2785484560 hasConceptScore W2785484560C185592680 @default.
• W2785484560 hasConceptScore W2785484560C190283241 @default.
• W2785484560 hasConceptScore W2785484560C203014093 @default.
• W2785484560 hasConceptScore W2785484560C2777511904 @default.
• W2785484560 hasConceptScore W2785484560C502942594 @default.
• W2785484560 hasConceptScore W2785484560C530470458 @default.

• next