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- W2785489794 abstract "Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most potent compounds, AV73, not only reduced hemolytic alpha-hemolysin production in S. aureus but also impeded in vitro biofilm formation. The effect of AV73 on bacterial proteomes and extracellular protein levels was analyzed by quantitative proteomics and revealed a significant down-regulation of major virulence and biofilm promoting proteins. To elucidate the mode of action of AV73, target identification was performed using affinity-based protein profiling (AfBPP), where among others YidC was identified as a target." @default.
- W2785489794 created "2018-02-23" @default.
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- W2785489794 date "2018-02-16" @default.
- W2785489794 modified "2023-10-14" @default.
- W2785489794 title "Dual Inhibitor of <i>Staphylococcus aureus</i> Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins" @default.
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- W2785489794 doi "https://doi.org/10.1021/acs.biochem.7b01271" @default.
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