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• W2785493310 abstract "HIV-1 transmission occurs mainly through mucosal tissues. During mucosal transmission, HIV-1 preferentially infects α4β7+ gut-homing CCR7- CD4+ effector/effector memory T cells (TEM) and results in massive depletion of these cells and other subsets of TEM in gut-associated lymphoid tissues. However, besides being eliminated by HIV-1, the role of TEM during the early stage of infection remains inconclusive. Here, using in vitro-induced α4β7+ gut-homing TEM (α4β7+ TEM), we found that α4β7+ TEM differentiated into CCR7+ CD4+ central memory T cells (TCM). This differentiation was HIV-1 independent but was inhibited by SB431542, a specific transforming growth factor β (TGF-β) receptor I kinase inhibitor. Consistently, TEM-to-TCM differentiation was observed in α4β7+ TEM stimulated with TGF-β1 (TGF-β). The TCM properties of the TGF-β-induced TEM-derived TCM (α4β7+ TCM) were confirmed by their enhanced CCL19 chemotaxis and the downregulation of surface CCR7 upon T cell activation in vitro Importantly, the effect of TGF-β on TCM differentiation also held in TEM directly isolated from peripheral blood. To investigate the significance of the TGF-β-dependent TEM-to-TCM differentiation in HIV/AIDS pathogenesis, we observed that both productively and latently infected α4β7+ TCM could differentiate from α4β7+ TEM in the presence of TGF-β during HIV-1 infection. Collectively, this study not only provides a new insight for the plasticity of TEM but also suggests that the TGF-β-dependent TEM-to-TCM differentiation is a previously unrecognized mechanism for the formation of latently infected TCM after HIV-1 infection.IMPORTANCE HIV-1 is the causative agent of HIV/AIDS, which has led to millions of deaths in the past 30 years. Although the implementation of highly active antiretroviral therapy has remarkably reduced the HIV-1-related morbidity and mortality, HIV-1 is not eradicated in treated patients due to the presence of latent reservoirs. Besides, the pathogenesis in CD4 T cells early after infection still remains elusive. Immediately after HIV-1 mucosal infection, CD4 T cells are preferentially infected and depleted. However, in addition to being depleted, the other roles of the CD4 T cells, especially the effector/effector memory T cells (TEM), in disease progression are not completely understood. The significance of this study is in revealing a novel mechanism for the formation of latently HIV-1-infected central memory CD4 T cells, a major latent reservoir from CD4 TEM after infection. Our findings suggest previously unrecognized roles of CD4 TEM in HIV-1 pathogenesis." @default.
• W2785493310 created "2018-02-23" @default.
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• W2785493310 date "2018-04-15" @default.
• W2785493310 modified "2023-10-14" @default.
• W2785493310 title "α ₄ β ₇ ⁺ CD4 ⁺ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor β1 during HIV-1 Infection" @default.
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• W2785493310 cites W1998870114 @default.
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• W2785493310 doi "https://doi.org/10.1128/jvi.01510-17" @default.
• W2785493310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5874435" @default.
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