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• W2785508766 abstract "l-Threonine is an important supplement in the food industry. It is currently produced through fermentation of Escherichia coli but requires additional purification steps to remove E. coli endotoxin. To avoid these steps, it is desirable to use Corynebacterium glutamicum, a microorganism generally regarded as safe. Engineering of C. glutamicum to increase production of l-threonine has mainly focused on gene regulation as well as l-threonine export or carbon flux depletion. In this study, we focus on the negative feedback inhibition produced by l-threonine on the enzyme homoserine kinase (ThrB). Although l-threonine binds to allosteric sites of aspartate kinase (LysC) and homoserine dehydrogenase (Hom), serving as a noncompetitive inhibitor, it acts as a competitive inhibitor on ThrB. This is problematic when attempting to engineer enzymes that are nonresponsive to increasing cellular concentrations of l-threonine. Using primary structure alignment as well as analysis of the Methanocaldococcus jannaschii Th..." @default.
• W2785508766 created "2018-02-23" @default.
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• W2785508766 date "2018-01-29" @default.
• W2785508766 modified "2023-09-26" @default.
• W2785508766 title "Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) of Corynebacterium glutamicum enhances L-Threonine Biosynthesis" @default.
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• W2785508766 doi "https://doi.org/10.2210/pdb5wat/pdb" @default.
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