Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785622014> ?p ?o ?g. }
- W2785622014 endingPage "1103" @default.
- W2785622014 startingPage "1094" @default.
- W2785622014 abstract "Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effects of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) alters the miRNA cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented procancer signaling consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor in lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes." @default.
- W2785622014 created "2018-02-23" @default.
- W2785622014 creator A5012074341 @default.
- W2785622014 creator A5020052233 @default.
- W2785622014 creator A5023294466 @default.
- W2785622014 creator A5030381252 @default.
- W2785622014 creator A5043671209 @default.
- W2785622014 creator A5046112250 @default.
- W2785622014 creator A5049723240 @default.
- W2785622014 creator A5050270681 @default.
- W2785622014 creator A5061477140 @default.
- W2785622014 creator A5067781317 @default.
- W2785622014 creator A5075755687 @default.
- W2785622014 creator A5078476014 @default.
- W2785622014 creator A5081156917 @default.
- W2785622014 creator A5084644058 @default.
- W2785622014 creator A5087398659 @default.
- W2785622014 date "2018-04-01" @default.
- W2785622014 modified "2023-10-16" @default.
- W2785622014 title "Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes" @default.
- W2785622014 cites W1522977578 @default.
- W2785622014 cites W1524048408 @default.
- W2785622014 cites W1583868454 @default.
- W2785622014 cites W1601681275 @default.
- W2785622014 cites W1609044025 @default.
- W2785622014 cites W1950118853 @default.
- W2785622014 cites W1974478155 @default.
- W2785622014 cites W1985844219 @default.
- W2785622014 cites W1988176449 @default.
- W2785622014 cites W1999315169 @default.
- W2785622014 cites W2007040134 @default.
- W2785622014 cites W2016485434 @default.
- W2785622014 cites W2017199818 @default.
- W2785622014 cites W2020645947 @default.
- W2785622014 cites W2027146979 @default.
- W2785622014 cites W2041449761 @default.
- W2785622014 cites W2042736191 @default.
- W2785622014 cites W2052798492 @default.
- W2785622014 cites W2055313665 @default.
- W2785622014 cites W2057419005 @default.
- W2785622014 cites W2060133690 @default.
- W2785622014 cites W2067326892 @default.
- W2785622014 cites W2075880806 @default.
- W2785622014 cites W2077938409 @default.
- W2785622014 cites W2082448279 @default.
- W2785622014 cites W2084770914 @default.
- W2785622014 cites W2088267142 @default.
- W2785622014 cites W2092021778 @default.
- W2785622014 cites W2092166712 @default.
- W2785622014 cites W2099676867 @default.
- W2785622014 cites W2112192177 @default.
- W2785622014 cites W2114104545 @default.
- W2785622014 cites W2114843025 @default.
- W2785622014 cites W2117692326 @default.
- W2785622014 cites W2117960515 @default.
- W2785622014 cites W2121354606 @default.
- W2785622014 cites W2126210405 @default.
- W2785622014 cites W2129273432 @default.
- W2785622014 cites W2133658633 @default.
- W2785622014 cites W2135299677 @default.
- W2785622014 cites W2140910902 @default.
- W2785622014 cites W2143340639 @default.
- W2785622014 cites W2146074826 @default.
- W2785622014 cites W2149441684 @default.
- W2785622014 cites W2156642107 @default.
- W2785622014 cites W2157824687 @default.
- W2785622014 cites W2169491358 @default.
- W2785622014 cites W2170551349 @default.
- W2785622014 cites W2259035271 @default.
- W2785622014 cites W2279910164 @default.
- W2785622014 cites W2296079189 @default.
- W2785622014 cites W2311732745 @default.
- W2785622014 cites W2318433546 @default.
- W2785622014 cites W2327541311 @default.
- W2785622014 cites W2340514456 @default.
- W2785622014 cites W2530674994 @default.
- W2785622014 cites W2560678530 @default.
- W2785622014 cites W2566863750 @default.
- W2785622014 cites W2598583594 @default.
- W2785622014 cites W2605487687 @default.
- W2785622014 cites W2952961321 @default.
- W2785622014 doi "https://doi.org/10.1016/j.ajpath.2017.12.009" @default.
- W2785622014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5963476" @default.
- W2785622014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29355516" @default.
- W2785622014 hasPublicationYear "2018" @default.
- W2785622014 type Work @default.
- W2785622014 sameAs 2785622014 @default.
- W2785622014 citedByCount "36" @default.
- W2785622014 countsByYear W27856220142018 @default.
- W2785622014 countsByYear W27856220142019 @default.
- W2785622014 countsByYear W27856220142020 @default.
- W2785622014 countsByYear W27856220142021 @default.
- W2785622014 countsByYear W27856220142022 @default.
- W2785622014 countsByYear W27856220142023 @default.
- W2785622014 crossrefType "journal-article" @default.
- W2785622014 hasAuthorship W2785622014A5012074341 @default.
- W2785622014 hasAuthorship W2785622014A5020052233 @default.
- W2785622014 hasAuthorship W2785622014A5023294466 @default.