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• W2785644002 abstract "Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal. A two-sample MR approach was used to examine the causal effect of diet/lifestyle upon risk of T2DM and glycemic traits. The protein intake-increasing allele C of FTO was significant associated with higher risk of T2DM (Beta ± SE = 0.104 ± 0.014, P = 4.40 × 10− 11), higher level of HOMA-IR (Beta ± SE = 0.016 ± 0.004, P = 9.55 × 10− 5), HOMA-B (Beta ± SE = 0.008 ± 0.003, P = 0.020). Using MR analyses, increased protein intake was causally associated with an increased risk of T2DM (Beta ± SE = 0.806 ± 0.260, P = 0.002). In addition, smoking cessation was causally associated with increased levels of glycemic traits such as HOMA-IR (Beta ± SE = 0.165 ± 0.072, P = 0.021), fasting insulin (Beta ± SE = 0.132 ± 0.066, P = 0.047) and fasting glucose (Beta ± SE = 0.132 ± 0.064, P = 0.039). These results provide evidence supporting a causal role for higher protein intake and smoking cession in T2DM. Our study provides further rationale for individuals at risk for diabetes to keep healthy lifestyle." @default.
• W2785644002 created "2018-02-23" @default.
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• W2785644002 date "2018-01-29" @default.
• W2785644002 modified "2023-09-26" @default.
• W2785644002 title "Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study" @default.
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• W2785644002 doi "https://doi.org/10.1186/s12944-018-0666-z" @default.
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