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- W2785672263 endingPage "1493" @default.
- W2785672263 startingPage "1483" @default.
- W2785672263 abstract "DNA double-strand breaks are considered one of the most lethal forms of DNA damage. Many effective anticancer therapeutic approaches used chemical and physical methods to generate DNA double-strand breaks in the cancer cells. They include: IR and drugs which mimetic its action, topoisomerase poisons, some alkylating agents or drugs which affected DNA replication process. On the other hand, cancer cells are mostly characterized by highly effective systems of DNA damage repair. There are two main DNA repair pathways used to fix double-strand breaks: NHEJ and HRR. Their activity leads to a decreased effect of chemotherapy. Targeting directly or indirectly the DNA double-strand breaks response by inhibitors seems to be an exciting option for anticancer therapy and is a part of novel trends that arise after the clinical success of PARP inhibitors. These trends will provide great opportunities for the development of DNA repair inhibitors as new potential anticancer drugs. The main objective of this article is to address these new promising advances." @default.
- W2785672263 created "2018-02-23" @default.
- W2785672263 creator A5004546574 @default.
- W2785672263 creator A5011214752 @default.
- W2785672263 creator A5011422263 @default.
- W2785672263 creator A5038319132 @default.
- W2785672263 creator A5069693901 @default.
- W2785672263 date "2019-05-16" @default.
- W2785672263 modified "2023-10-18" @default.
- W2785672263 title "DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics" @default.
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