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- W2785712658 abstract "The endothelium plays a pivotal role in vascular biology. The endothelium is the primary site of injury in thrombotic microangiopathies including malignant hypertension. Endothelial injury in thrombotic microangiopathies is the result of increased shear stress, toxins, and/or dysregulated complement activation. Endothelial injury can lead to microvascular thrombosis resulting in ischemia and organ dysfunction, the clinical hallmarks of thrombotic microangiopathies. Currently, available therapies target the underlying mechanisms that lead to endothelial injury in these conditions. Ongoing investigations aim at identifying drugs that protect the endothelium. J Am Soc Hypertens 2016;10(4):352–359. Published by Elsevier Inc. on behalf of American Society of Hypertension." @default.
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- W2785712658 date "2016-01-01" @default.
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- W2785712658 title "Review Article The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy" @default.
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