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- W2785771207 startingPage "248153" @default.
- W2785771207 abstract "Citrobacter rodentium is a mouse-restricted pathogen that has long been used as an in vivo model for two important human intestinal pathogen enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC). And yet, in contrast to E. coli, little is known about the bacteriophages (phages), bacterial viruses, that infect C. rodentium, reflecting in part a need to isolate and comparatively analyze phages associated with this bacterial species. Here, we isolated two novel virulent phages CrRp3 and CrRp10 that infect C. rodentium and conduct in vitro and comparative genomic studies with other, related phages. Whole-genome analyses revealed that CrRp3 and CrRp10 phages are members of Sp6virus and T4virus genera, respectively. In addition, we show that these phages have pervasively mosaic genome architectures by actively evolving with several horizontal genetic exchange and mutational events. Phylogenetic analyses showed that these phages are more closely related to E. coli phages than those infecting Citrobacter genus, suggesting that CrRp3 and CrRp10 may have evolved from E. coli phages rather than Citrobacter spp. phages." @default.
- W2785771207 created "2018-02-23" @default.
- W2785771207 creator A5025729223 @default.
- W2785771207 creator A5041753568 @default.
- W2785771207 creator A5089913383 @default.
- W2785771207 date "2018-01-15" @default.
- W2785771207 modified "2023-09-23" @default.
- W2785771207 title "Comparative genomics and phylogeny unveil lineage diversification of Citrobacter rodentium polyvalent bacteriophage" @default.
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- W2785771207 hasPublicationYear "2018" @default.
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