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- W2785786292 abstract "The present study were The immune system plays an important role in defense mechanism andprotects the body against various antigens and infectious diseases. The homeostaticbalance is maintained by the stimulation or suppression of immune cells and it keepsthe body in normal healthy condition. Thus, the immune modulator plays a vital rolein maintaining the immune system.In this study, the immunomodulatory activity of purified Propolis was studiedon cyclophosphamide (CYP) treated immuno-suppressed Swiss albino rats. Theimmunomodulatory activity of Propolis was compared with standard immuneactivating drug levamisole.The CYP is an alkylating drug that belongs to the subclass of nitrogenmustard. It is commonly given as a chemotherapeutic drug for cancer treatment and asan immunosuppressant for organ transplantation and autoimmune disorder (Moore1991)133. CYP also causes some side effects such as myelosuppression, immunesuppression and oxidative stress which may be life threatening (Wang et al 2011)134.The inactive form of CYP is activated by the liver enzyme cytochrome P450 to 4-hydroxycyclophosphamide which transferred to other organs as well. Then, 4-hydroxycyclophosphamide is further converted to phosphoramide mustard andacrolein. The phosphoramide mustard causes cytotoxic damage to cells and acroleincauses some side effects (Sun & Peng 2008)135.In this study, CYP is given to the Swiss albino rats to suppress the immunesystem and induce oxidative stress. The cyclophosphamide effect is expected toreduce the activity of hematological parameters, cell mediated immune responses andmacrophage production. Moreover, CYP impaired the organs through its toxicmetabolites and caused oxidative stress. The effect of Propolison CYP inducedimmune-toxicity was examined through myelosuppression, immune suppression andoxidative damage.CONCLUSION: In conclusion, the present study has proved that Propolis not only enhance theimmune system but also protect the organs against oxidative stress. The results of thepresent study recommend that Propolis could be a prominent naturalimmunomodulating molecule with therapeutic value." @default.
- W2785786292 created "2018-02-23" @default.
- W2785786292 creator A5087916546 @default.
- W2785786292 date "2017-05-01" @default.
- W2785786292 modified "2023-09-27" @default.
- W2785786292 title "Immunomodulatory Activity of Ethanolic Extract of Propolis (Apismellifera Linn) on Cyclophosphamide Treated Immunosuppressed Rats" @default.
- W2785786292 hasPublicationYear "2017" @default.
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