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- W2785791389 endingPage "665" @default.
- W2785791389 startingPage "641" @default.
- W2785791389 abstract "The arginase enzyme developed in early life forms and was maintained during evolution. As the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The urea cycle provides protection against excess ammonia, while l-ornithine is needed for cell proliferation, collagen formation, and other physiological functions. In mammals, increases in arginase activity have been linked to dysfunction and pathologies of the cardiovascular system, kidney, and central nervous system and also to dysfunction of the immune system and cancer. Two important aspects of the excessive activity of arginase may be involved in diseases. First, overly active arginase can reduce the supply of l-arginine needed for the production of nitric oxide (NO) by NO synthase. Second, too much l-ornithine can lead to structural problems in the vasculature, neuronal toxicity, and abnormal growth of tumor cells. Seminal studies have demonstrated that increased formation of reactive oxygen species and key inflammatory mediators promote this pathological elevation of arginase activity. Here, we review the involvement of arginase in diseases affecting the cardiovascular, renal, and central nervous system and cancer and discuss the value of therapies targeting the elevated activity of arginase." @default.
- W2785791389 created "2018-02-23" @default.
- W2785791389 creator A5001111641 @default.
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- W2785791389 creator A5032953381 @default.
- W2785791389 creator A5042136937 @default.
- W2785791389 creator A5057027087 @default.
- W2785791389 date "2018-04-01" @default.
- W2785791389 modified "2023-10-17" @default.
- W2785791389 title "Arginase: A Multifaceted Enzyme Important in Health and Disease" @default.
- W2785791389 cites W104355213 @default.
- W2785791389 cites W1481109427 @default.
- W2785791389 cites W1487824903 @default.
- W2785791389 cites W1490514271 @default.
- W2785791389 cites W1497879842 @default.
- W2785791389 cites W1526905466 @default.
- W2785791389 cites W1546229166 @default.
- W2785791389 cites W1572706276 @default.
- W2785791389 cites W1581040284 @default.
- W2785791389 cites W1586801024 @default.
- W2785791389 cites W1591881963 @default.
- W2785791389 cites W1594036338 @default.
- W2785791389 cites W1607173640 @default.
- W2785791389 cites W1654464743 @default.
- W2785791389 cites W165962183 @default.
- W2785791389 cites W1764674136 @default.
- W2785791389 cites W1789051939 @default.
- W2785791389 cites W1819661950 @default.
- W2785791389 cites W183432655 @default.
- W2785791389 cites W1842542340 @default.
- W2785791389 cites W1843927557 @default.
- W2785791389 cites W1860163656 @default.
- W2785791389 cites W1895925833 @default.
- W2785791389 cites W1952416355 @default.
- W2785791389 cites W1964115007 @default.
- W2785791389 cites W1971110044 @default.
- W2785791389 cites W1971419882 @default.
- W2785791389 cites W1972090872 @default.
- W2785791389 cites W1972314100 @default.
- W2785791389 cites W1973905295 @default.
- W2785791389 cites W1975698396 @default.
- W2785791389 cites W1979346881 @default.
- W2785791389 cites W1983205909 @default.
- W2785791389 cites W1985939862 @default.
- W2785791389 cites W1986618826 @default.
- W2785791389 cites W1987432705 @default.
- W2785791389 cites W1987659318 @default.
- W2785791389 cites W1988177565 @default.
- W2785791389 cites W1988559818 @default.
- W2785791389 cites W1989273417 @default.
- W2785791389 cites W1990205291 @default.
- W2785791389 cites W1990235141 @default.
- W2785791389 cites W1990829099 @default.
- W2785791389 cites W1991116591 @default.
- W2785791389 cites W1992002708 @default.
- W2785791389 cites W1992732798 @default.
- W2785791389 cites W1994044284 @default.
- W2785791389 cites W1994358412 @default.
- W2785791389 cites W1996295305 @default.
- W2785791389 cites W1997023449 @default.
- W2785791389 cites W1998432289 @default.
- W2785791389 cites W1999416757 @default.
- W2785791389 cites W1999442689 @default.
- W2785791389 cites W1999853237 @default.
- W2785791389 cites W1999952553 @default.
- W2785791389 cites W2000725338 @default.
- W2785791389 cites W2001461795 @default.
- W2785791389 cites W2002320331 @default.
- W2785791389 cites W2002631122 @default.
- W2785791389 cites W2003820681 @default.
- W2785791389 cites W2004769084 @default.
- W2785791389 cites W2005787679 @default.
- W2785791389 cites W2006705030 @default.
- W2785791389 cites W2008869160 @default.
- W2785791389 cites W2009085606 @default.
- W2785791389 cites W2011462671 @default.
- W2785791389 cites W2012998052 @default.
- W2785791389 cites W2013248933 @default.
- W2785791389 cites W2016773001 @default.
- W2785791389 cites W2017590002 @default.
- W2785791389 cites W2017755915 @default.
- W2785791389 cites W2018037431 @default.
- W2785791389 cites W2018261122 @default.
- W2785791389 cites W2018519933 @default.
- W2785791389 cites W2018600707 @default.
- W2785791389 cites W2019788114 @default.
- W2785791389 cites W2020818523 @default.
- W2785791389 cites W202196835 @default.
- W2785791389 cites W2023917164 @default.
- W2785791389 cites W2024435755 @default.
- W2785791389 cites W2026026958 @default.
- W2785791389 cites W2026707952 @default.
- W2785791389 cites W2026971330 @default.
- W2785791389 cites W2028505614 @default.
- W2785791389 cites W2029491963 @default.
- W2785791389 cites W2031195983 @default.
- W2785791389 cites W2033546154 @default.
- W2785791389 cites W2035817205 @default.