FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785898451> ?p ?o ?g. }

• W2785898451 endingPage "403" @default.
• W2785898451 startingPage "393" @default.
• W2785898451 abstract "BACKGROUND:The endothelial glycocalyx plays a decisive role in maintaining vascular homeostasis. Previous animal models have mainly focused on in-vitro experiments or the isolated beating guinea pig heart. To further evaluate underlying mechanisms of up- and down regulation, knock-out animals seem to be a promising option. OBJECTIVE:Aim of the present study was to evaluate if an isolated mouse-heart model is suitable for glycocalyx research. METHODS:Isolated beating mouse hearts (C57/Bl6J) underwent warm, no-flow ischemia and successive reperfusion. Coronary effluent was analyzed by ELISA and Western blot for the glycocalyx core protein: syndecan-1. Hearts were prepared for either immunofluorescence or electron microscopy and lysed for Western blot analysis. RESULTS:An endothelial glycocalyx covering the total capillary circumference and syndecan-1 were detected by electron and immunofluorescence microscopy. Ischemia/reperfusion seriously deteriorated both findings. Confoundingly, syndecan-1 was not detectable either in the coronary effluent or in the lysates of blood-free hearts by ELISA or Western blot technique. CONCLUSIONS:Blood vessels of mouse hearts contain an endothelial glycocalyx comparable to that of other animals also with respect to its core protein syndecan-1. But, for studies including quantification of intravascular soluble glycocalyx constituents, the amount of syndecan-1 in mouse hearts seems to be too low." @default.
• W2785898451 created "2018-02-23" @default.
• W2785898451 creator A5000863663 @default.
• W2785898451 creator A5006547618 @default.
• W2785898451 creator A5017800323 @default.
• W2785898451 creator A5035467211 @default.
• W2785898451 creator A5037905869 @default.
• W2785898451 creator A5041866930 @default.
• W2785898451 creator A5042610251 @default.
• W2785898451 creator A5046908944 @default.
• W2785898451 creator A5054938838 @default.
• W2785898451 creator A5065180441 @default.
• W2785898451 creator A5079502549 @default.
• W2785898451 creator A5091089375 @default.
• W2785898451 date "2018-06-28" @default.
• W2785898451 modified "2023-10-18" @default.
• W2785898451 title "Chances and limitations of isolated mouse heart models for investigating the endothelial glycocalyx1" @default.
• W2785898451 cites W1578062386 @default.
• W2785898451 cites W1977668366 @default.
• W2785898451 cites W1983557577 @default.
• W2785898451 cites W2014934849 @default.
• W2785898451 cites W2015714938 @default.
• W2785898451 cites W2020732104 @default.
• W2785898451 cites W2032464831 @default.
• W2785898451 cites W2040242558 @default.
• W2785898451 cites W2042042661 @default.
• W2785898451 cites W2042977576 @default.
• W2785898451 cites W2060613470 @default.
• W2785898451 cites W2065350174 @default.
• W2785898451 cites W2072725772 @default.
• W2785898451 cites W2075603768 @default.
• W2785898451 cites W2090858727 @default.
• W2785898451 cites W2105279526 @default.
• W2785898451 cites W2111247242 @default.
• W2785898451 cites W2112223256 @default.
• W2785898451 cites W2120056578 @default.
• W2785898451 cites W2143965055 @default.
• W2785898451 cites W2145415920 @default.
• W2785898451 cites W2152252241 @default.
• W2785898451 cites W2152934519 @default.
• W2785898451 cites W2162312379 @default.
• W2785898451 cites W2165130888 @default.
• W2785898451 cites W2256884124 @default.
• W2785898451 cites W2509095239 @default.
• W2785898451 cites W2610255045 @default.
• W2785898451 doi "https://doi.org/10.3233/ch-170327" @default.
• W2785898451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29400664" @default.
• W2785898451 hasPublicationYear "2018" @default.
• W2785898451 type Work @default.
• W2785898451 sameAs 2785898451 @default.
• W2785898451 citedByCount "3" @default.
• W2785898451 countsByYear W27858984512020 @default.
• W2785898451 crossrefType "journal-article" @default.
• W2785898451 hasAuthorship W2785898451A5000863663 @default.
• W2785898451 hasAuthorship W2785898451A5006547618 @default.
• W2785898451 hasAuthorship W2785898451A5017800323 @default.
• W2785898451 hasAuthorship W2785898451A5035467211 @default.
• W2785898451 hasAuthorship W2785898451A5037905869 @default.
• W2785898451 hasAuthorship W2785898451A5041866930 @default.
• W2785898451 hasAuthorship W2785898451A5042610251 @default.
• W2785898451 hasAuthorship W2785898451A5046908944 @default.
• W2785898451 hasAuthorship W2785898451A5054938838 @default.
• W2785898451 hasAuthorship W2785898451A5065180441 @default.
• W2785898451 hasAuthorship W2785898451A5079502549 @default.
• W2785898451 hasAuthorship W2785898451A5091089375 @default.
• W2785898451 hasConcept C104317684 @default.
• W2785898451 hasConcept C123012128 @default.
• W2785898451 hasConcept C126322002 @default.
• W2785898451 hasConcept C142724271 @default.
• W2785898451 hasConcept C1491633281 @default.
• W2785898451 hasConcept C159654299 @default.
• W2785898451 hasConcept C185592680 @default.
• W2785898451 hasConcept C202751555 @default.
• W2785898451 hasConcept C203014093 @default.
• W2785898451 hasConcept C2776415932 @default.
• W2785898451 hasConcept C2778236600 @default.
• W2785898451 hasConcept C2780098789 @default.
• W2785898451 hasConcept C541997718 @default.
• W2785898451 hasConcept C55493867 @default.
• W2785898451 hasConcept C65001120 @default.
• W2785898451 hasConcept C71924100 @default.
• W2785898451 hasConcept C86803240 @default.
• W2785898451 hasConceptScore W2785898451C104317684 @default.
• W2785898451 hasConceptScore W2785898451C123012128 @default.
• W2785898451 hasConceptScore W2785898451C126322002 @default.
• W2785898451 hasConceptScore W2785898451C142724271 @default.
• W2785898451 hasConceptScore W2785898451C1491633281 @default.
• W2785898451 hasConceptScore W2785898451C159654299 @default.
• W2785898451 hasConceptScore W2785898451C185592680 @default.
• W2785898451 hasConceptScore W2785898451C202751555 @default.
• W2785898451 hasConceptScore W2785898451C203014093 @default.
• W2785898451 hasConceptScore W2785898451C2776415932 @default.
• W2785898451 hasConceptScore W2785898451C2778236600 @default.
• W2785898451 hasConceptScore W2785898451C2780098789 @default.
• W2785898451 hasConceptScore W2785898451C541997718 @default.
• W2785898451 hasConceptScore W2785898451C55493867 @default.
• W2785898451 hasConceptScore W2785898451C65001120 @default.
• W2785898451 hasConceptScore W2785898451C71924100 @default.

• next