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- W2785917385 abstract "Abstract The giant ciliate Stentor coeruleus is a classical model system for studying regeneration and morphogenesis at the level of a single cell. Stentor are polarized cells with a complex subcellular architecture. The anterior of the cell is marked by an array of cilia, known as the oral apparatus. This feeding organelle can be induced to shed and regenerate in a series of reproducible morphological steps, previously shown to require transcription. We used RNAseq to assay the dynamic changes in Stento ’s transcriptome during regeneration with high temporal resolution, allowing us to identify five distinct waves of gene expression. We show that the oral apparatus is a model for organelle regeneration, as well as for centriole assembly and ciliogenesis as many conserved genes involved in those processes are induced. Additionally, we find genes involved in signaling, cell cycle regulation, transcription, and RNA binding to be expressed at distinct stages of organelle regeneration, suggesting that the morphological steps of regeneration are driven by a complex regulatory system." @default.
- W2785917385 created "2018-02-23" @default.
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- W2785917385 date "2017-12-29" @default.
- W2785917385 modified "2023-09-24" @default.
- W2785917385 title "The Transcriptional Program of Regeneration in the Giant Single Cell, Stentor coeruleus" @default.
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- W2785917385 doi "https://doi.org/10.1101/240788" @default.
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