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• W2786019151 abstract "Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A major difference between SCLC and other forms of lung cancer is that SCLC tumors often respond well to chemotherapy initially; unfortunately, resistant tumors rapidly recur. In addition, despite a large number of clinical trials with a variety of therapeutic agents, little progress has been achieved in the past three decades in improving the survival of SCLC patients. These clinical observations indicate that SCLC tumors have a high degree of plasticity and rapid adaptability to changes in growth conditions. Here we consider recent evidence pointing to several levels of heterogeneity in SCLC that may explain the ability of these tumors to adjust to different microenvironment and therapeutics. In particular, we review new data pointing to the existence of several subpopulations of tumor cells that interact with each other to promote tumor growth. We also discuss how SCLC tumors that look similar at the histopathological level may actually represent distinct subtypes of tumors and how these differences impact the response to specific therapeutic agents. A better understanding of genetic and cellular heterogeneity will guide the development of personalized approaches to help SCLC patients." @default.
• W2786019151 created "2018-02-23" @default.
• W2786019151 creator A5022393123 @default.
• W2786019151 creator A5072246467 @default.
• W2786019151 creator A5073510275 @default.
• W2786019151 date "2018-02-01" @default.
• W2786019151 modified "2023-09-30" @default.
• W2786019151 title "Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models" @default.
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• W2786019151 doi "https://doi.org/10.21037/tlcr.2018.01.15" @default.
• W2786019151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5835592" @default.
• W2786019151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29535910" @default.
• W2786019151 hasPublicationYear "2018" @default.
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