Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786081330> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2786081330 endingPage "184.20" @default.
- W2786081330 startingPage "184.20" @default.
- W2786081330 abstract "Abstract Tumor necrosis factor (TNF) plays dualistic pro-inflammatory and immune suppressive roles that lead to unpredictable outcomes of TNF blockade in autoimmune disease. Recent evidence has identified contrasting co-stimulatory effects of TNF on effector T cells and regulatory T cells in controlling autoimmunity. The objective of this study was to determine whether CD4+ T cell autonomous TNFR1 and TNFR2 differentially regulate IL-2 production. We utilize B10.A 5C.C7 TCR Tg Rag2-/- IL-2-GFP reporter mice that are deficient for TNFR1 and/or TNFR2 and memTNFΔ1-12 FoxP3-GFP reporter mice that encode an uncleavable tmTNF to demonstrate that TNFR2, but not TNFR1, and membrane, but not soluble, TNF promote Il2 promoter activity and decrease Il2 mRNA decay to increase IL-2 production in response to CD4+ T cell stimulation. We further demonstrate differential DNA binding of NF-κB in TNFR1- and TNFR2-deficient CD4+ T cells following activation. Adoptive transfer of naive CD4+ T cells from TNFR2-deficient IL-2-GFP heterozygous (IL-2+/-), but not IL-2-GFP homozygous (IL-2-/-), 5C.C7 Rag2-/- TCR Tg mice into B10.A Rag2-/- hosts and subsequent immunization with MCC88-103 + LPS yielded greater IL-17 production upon CD4+ T cell re-challenge in comparison to transfer of TNFR2-sufficient 5C.C7 TCR CD4+ T cells. Taken together, these results suggest that selective blockade of TNFR2 on CD4+ T cells is sufficient to inhibit IL-2 production and promote TH17 differentiation." @default.
- W2786081330 created "2018-02-23" @default.
- W2786081330 creator A5019057031 @default.
- W2786081330 creator A5035061804 @default.
- W2786081330 creator A5048020370 @default.
- W2786081330 date "2015-05-01" @default.
- W2786081330 modified "2023-09-23" @default.
- W2786081330 title "Lack of TNFR2 expression by CD4+ T cells limits IL-2 production and promotes Th17 differentiation (BA11P.138)" @default.
- W2786081330 doi "https://doi.org/10.4049/jimmunol.194.supp.184.20" @default.
- W2786081330 hasPublicationYear "2015" @default.
- W2786081330 type Work @default.
- W2786081330 sameAs 2786081330 @default.
- W2786081330 citedByCount "0" @default.
- W2786081330 crossrefType "journal-article" @default.
- W2786081330 hasAuthorship W2786081330A5019057031 @default.
- W2786081330 hasAuthorship W2786081330A5035061804 @default.
- W2786081330 hasAuthorship W2786081330A5048020370 @default.
- W2786081330 hasConcept C153911025 @default.
- W2786081330 hasConcept C17991360 @default.
- W2786081330 hasConcept C19317047 @default.
- W2786081330 hasConcept C203014093 @default.
- W2786081330 hasConcept C2776090121 @default.
- W2786081330 hasConcept C2779727006 @default.
- W2786081330 hasConcept C86803240 @default.
- W2786081330 hasConcept C8891405 @default.
- W2786081330 hasConcept C90375314 @default.
- W2786081330 hasConcept C95444343 @default.
- W2786081330 hasConceptScore W2786081330C153911025 @default.
- W2786081330 hasConceptScore W2786081330C17991360 @default.
- W2786081330 hasConceptScore W2786081330C19317047 @default.
- W2786081330 hasConceptScore W2786081330C203014093 @default.
- W2786081330 hasConceptScore W2786081330C2776090121 @default.
- W2786081330 hasConceptScore W2786081330C2779727006 @default.
- W2786081330 hasConceptScore W2786081330C86803240 @default.
- W2786081330 hasConceptScore W2786081330C8891405 @default.
- W2786081330 hasConceptScore W2786081330C90375314 @default.
- W2786081330 hasConceptScore W2786081330C95444343 @default.
- W2786081330 hasIssue "1_Supplement" @default.
- W2786081330 hasLocation W27860813301 @default.
- W2786081330 hasOpenAccess W2786081330 @default.
- W2786081330 hasPrimaryLocation W27860813301 @default.
- W2786081330 hasRelatedWork W1535737655 @default.
- W2786081330 hasRelatedWork W1978189790 @default.
- W2786081330 hasRelatedWork W1998679748 @default.
- W2786081330 hasRelatedWork W2007702854 @default.
- W2786081330 hasRelatedWork W2023415465 @default.
- W2786081330 hasRelatedWork W2076903534 @default.
- W2786081330 hasRelatedWork W2262741309 @default.
- W2786081330 hasRelatedWork W2747317233 @default.
- W2786081330 hasRelatedWork W3018986011 @default.
- W2786081330 hasRelatedWork W3118867675 @default.
- W2786081330 hasVolume "194" @default.
- W2786081330 isParatext "false" @default.
- W2786081330 isRetracted "false" @default.
- W2786081330 magId "2786081330" @default.
- W2786081330 workType "article" @default.