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- W2786131029 abstract "Crohn's disease (CD) and ulcerative colitis (UC) are the two major diseases that make up the inflammatory bowel disease (IBD). Studies indicate that several genes, in addition to those involved in the modulation of the immune response, are differentially expressed in patients with CD. vs UC. The discovery of microRNAs (miRNAs) as important regulators of gene expression and their role in human diseases, including inflammatory and chronic degenerative diseases, have indicated miRNAs as ideal candidates for diagnostic biomarkers, prognostics and potential therapeutic targets. An important feature of miRNAs is their stability and easy detection in body fluids. To identify deregulated miRNAs in DII and to apply bioinformatic analysis strategies to identify target mRNAs and molecular pathways modulated by miRNAs through meta-analysis of literature data. A meta-analysis was performed for the identification of miRNA expression data in IBD.. Controls were used in bioinformatic analysis to predict the target mRNAs regulated by these miRNAs. The results showed 6 CD miRNAs with increased expression and 51 UC. On the other hand, miRNAs with decreased expression were found 51 CD and 26 UC. The miRNAs that showed the greatest number of interactions with DII deregulated genes were let-7a-5p, let-7b-5p and miR-199a-5p, miR-150-5p, miR-362-3p and miR-224- 5p. In the RCU were -155-5p and miR-24-5p, miR-335-5p and miR-16-5p. Suggesting that they may play an important role in the molecular mechanisms of disease. Several interrelated genes and miRNAs were identified as potential regulators of gene expression. Such miRNAs and genes may play important roles in the development and progression of inflammatory bowel disease. The miRNAs may be useful for the future development of more accurate treatment strategies for patients with DII." @default.
- W2786131029 created "2018-02-23" @default.
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- W2786131029 date "2018-01-01" @default.
- W2786131029 modified "2023-09-27" @default.
- W2786131029 title "P121 THE ROLE OF MICRORNAS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE - A METANALYSIS REVIEW" @default.
- W2786131029 doi "https://doi.org/10.1053/j.gastro.2017.11.167" @default.
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