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• W2786146867 endingPage "e1007178" @default.
• W2786146867 startingPage "e1007178" @default.
• W2786146867 abstract "The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together with the concentration-limiting scaffold protein Axin, in a “destruction complex” that directs the phosphorylation and consequent proteasomal degradation of the transcriptional activator β-catenin, thereby preventing signaling in the Wnt-off state. Following Wnt stimulation, Axin is recruited to a multiprotein “signalosome” required for pathway activation. Whereas it is well-documented that APC is essential in the destruction complex, APC’s role in this complex remains elusive. Here, we demonstrate in Drosophila that Axin exists in two distinct phosphorylation states in Wnt-off and Wnt-on conditions, respectively, that underlie its roles in the destruction complex and signalosome. These two Axin phosphorylation states are catalyzed by glycogen synthase kinase 3 (GSK3), and unexpectedly, completely dependent on APC in both unstimulated and Wnt-stimulated conditions. In a major revision of the classical model, we show that APC is essential not only in the destruction complex, but also for the rapid transition in Axin that occurs after Wnt stimulation and Axin’s subsequent association with the Wnt co-receptor LRP6/Arrow, one of the earliest steps in pathway activation. We propose that this novel requirement for APC in Axin regulation through phosphorylation both prevents signaling in the Wnt-off state and promotes signaling immediately following Wnt stimulation." @default.
• W2786146867 created "2018-02-23" @default.
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• W2786146867 date "2018-02-06" @default.
• W2786146867 modified "2023-10-01" @default.
• W2786146867 title "Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC" @default.
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• W2786146867 cites W1872492855 @default.
• W2786146867 cites W1964793476 @default.
• W2786146867 cites W1965372133 @default.
• W2786146867 cites W1970146368 @default.
• W2786146867 cites W1970619948 @default.
• W2786146867 cites W1976226144 @default.
• W2786146867 cites W1991461487 @default.
• W2786146867 cites W1995047706 @default.
• W2786146867 cites W1996984755 @default.
• W2786146867 cites W2003637983 @default.
• W2786146867 cites W2006419043 @default.
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• W2786146867 cites W2010044764 @default.
• W2786146867 cites W2010155516 @default.
• W2786146867 cites W2012039807 @default.
• W2786146867 cites W2013460988 @default.
• W2786146867 cites W2014440034 @default.
• W2786146867 cites W2014460650 @default.
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• W2786146867 cites W2023594205 @default.
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• W2786146867 cites W2037611829 @default.
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• W2786146867 cites W2064027874 @default.
• W2786146867 cites W2065431388 @default.
• W2786146867 cites W2065864607 @default.
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• W2786146867 cites W2067446542 @default.
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• W2786146867 cites W2072335762 @default.
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• W2786146867 cites W2133769699 @default.
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• W2786146867 cites W2147592498 @default.
• W2786146867 cites W2147666645 @default.
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• W2786146867 cites W2155308439 @default.
• W2786146867 cites W2158021558 @default.
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• W2786146867 doi "https://doi.org/10.1371/journal.pgen.1007178" @default.
• W2786146867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5800574" @default.
• W2786146867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29408853" @default.
• W2786146867 hasPublicationYear "2018" @default.
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