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- W2786169098 endingPage "e0191652" @default.
- W2786169098 startingPage "e0191652" @default.
- W2786169098 abstract "Codon adaptation index (CAI) is a measure of synonymous codon usage biases given a usage reference. Through mutation, selection, and drift, viruses can optimize their replication efficiency and produce more offspring, which could increase the chance of secondary transmission. To evaluate how higher CAI towards the host has been associated with higher viral titers, we explored temporal trends of several historic and extensively sequenced zoonotic flaviviruses and relationships within the genus itself. To showcase evolutionary and epidemiological relationships associated with silent, adaptive synonymous changes of viruses, we used codon usage tables from human housekeeping and antiviral immune genes, as well as tables from arthropod vectors and vertebrate species involved in the flavivirus maintenance cycle. We argue that temporal trends of CAI changes could lead to a better understanding of zoonotic emergences, evolutionary dynamics, and host adaptation. CAI appears to help illustrate historically relevant trends of well-characterized viruses, in different viral species and genetic diversity within a single species. CAI can be a useful tool together with in vivo and in vitro kinetics, phylodynamics, and additional functional genomics studies to better understand species trafficking and viral emergence in a new host." @default.
- W2786169098 created "2018-02-23" @default.
- W2786169098 creator A5027383447 @default.
- W2786169098 creator A5081469758 @default.
- W2786169098 creator A5082053897 @default.
- W2786169098 date "2018-01-31" @default.
- W2786169098 modified "2023-09-23" @default.
- W2786169098 title "Does adaptation to vertebrate codon usage relate to flavivirus emergence potential?" @default.
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