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- W2786183760 abstract "Over last few years, the rapid growth of optical technologies for biomedical imaging makes possible to reveal important biological information of tissues from light-tissue interaction. The emerging interest on new biomedical imaging techniques is motivated by the necessity to detect malignant cells and other diseases at early growth stages. The limited penetration depth of optical energy in biological media is primarily due to the high level of optical scattering. In addition, the diffusion of light in biological tissues limits the spatial resolution of the images acquired. The optoacoustic technique overcomes these issues combining the high contrast of optical imaging with the high spatial resolution of ultrasound systems in deep tissues. As well, the low scattering of the ultrasound waves produced in the biological tissues facilitates the acquisition of high-resolution images. Two more important aspects to be considered in optoacoustic applications for a functional imaging are the use of optical contrast agents to increase the absorption of optical energy in those areas where the scattering is dominant, and the amount of optical energy delivered by laser sources to penetrate in depth. The necessity of compact and cost-effective laser sources with the characteristics required by optoacoustic applications has encouraged the studies presented in this thesis, proposing the use of high-power diode lasers instead of the classical solid state lasers. Generally, solid-state lasers like Nd:YAG and optical parametric oscillators are used for the generation of optoacoustic signals, but their use in clinical environment is limited by their high costs, low repetition rates and bulky sizes. On the other hand, high-power diode lasers emerge as a potential alternative, due to their relatively low costs, high repetition rates required for fast image acquisition and compact sizes. However, the power of high-power diode lasers is still relatively low compared to solid-state lasers and for this reason they need to be combined in arrays to reach the amount of the optical power required for optoacoustic applications. An optoacoustic setup based on small arrays of high-power diode lasers has been implemented and improved along the studies presented in this thesis. Optoacoustic experiments have been performed at different wavelengths using several kinds of absorbers hosted in a quartz cuvette or embedded within a phantom that simulates the optical scattering of a soft tissue. Solutions of carbon nanotubes, graphene oxide and gold nanorods have been used as absorbers in the experiments. The first experiments done in free space to focus the light in the absorbers have been improved by using optical fibers in a second stage. Lastly, some commercially available diode laser bars have been proposed to replace the high-power diode lasers with the aim to increase the optical power for future implementations in the optoacoustic systems. Optical simulations have demonstrated the possibility to focus the beam of diode laser bars operating at different wavelengths into optical fibers by means of cylindrical microlenses. In a second step, the diode laser bars have been assembled together to simulate a multi-wavelength system. The beams have been combined by dichroic mirrors and focused in a multi-mode optical fiber. This research work has opened up new lines of investigation in the development of high-power laser sources for optoacoustic endoscopy and tomography in biomedical applications." @default.
- W2786183760 created "2018-02-23" @default.
- W2786183760 creator A5073442677 @default.
- W2786183760 date "2017-01-01" @default.
- W2786183760 modified "2023-09-24" @default.
- W2786183760 title "Design and development of a multi-wavelength optoacoustic system based on high-power diode laser sources. Optoacoustic signal generation with nanoparticles for biomedical applications" @default.
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