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• W2786249979 endingPage "1522" @default.
• W2786249979 startingPage "1517" @default.
• W2786249979 abstract "DNAzymes are catalytic DNA molecules that can perform a variety of reactions. Although advances have been made in obtaining DNAzymes via in vitro selection and many of them have been developed into sensors and imaging agents for metal ions, bacteria, and other molecules, the structural features responsible for these enzymatic reactions are still not well understood. Previous studies of the 8-17 DNAzyme have suggested conserved guanines close to the phosphodiester transfer site may play a role in the catalytic reaction. To identify the specific guanine and functional group of the guanine responsible for the reaction, we herein report the effects of replacing G1.1 and G14 (G; p Ka,N1 = 9.4) with analogues with a different p Ka at the N1 position, such as inosine (G14I; p Ka,N1 = 8.7), 2,6-diaminopurine (G14diAP; p Ka,N1 = 5.6), and 2-aminopurine (G14AP; p Ka,N1 = 3.8) on pH-dependent reaction rates. A comparison of the pH dependence of the reaction rates of these DNAzymes demonstrated that G14 in the bulge loop next to the cleavage site, is involved in proton transfer at the catalytic site. In contrast, we did not find any evidence of G1.1 being involved in acid-base catalysis. These results support general acid-base catalysis as a feasible strategy used in DNA catalysis, as in RNA and protein enzymes." @default.
• W2786249979 created "2018-02-23" @default.
• W2786249979 creator A5011415820 @default.
• W2786249979 creator A5029742005 @default.
• W2786249979 creator A5030686904 @default.
• W2786249979 date "2018-02-01" @default.
• W2786249979 modified "2023-10-01" @default.
• W2786249979 title "Evidence of a General Acid–Base Catalysis Mechanism in the 8–17 DNAzyme" @default.
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• W2786249979 cites W1972719314 @default.
• W2786249979 cites W1974000520 @default.
• W2786249979 cites W1977092617 @default.
• W2786249979 cites W1977709085 @default.
• W2786249979 cites W1979073863 @default.
• W2786249979 cites W1983825093 @default.
• W2786249979 cites W1985922002 @default.
• W2786249979 cites W1991758942 @default.
• W2786249979 cites W1992015169 @default.
• W2786249979 cites W1996954846 @default.
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• W2786249979 cites W2003014328 @default.
• W2786249979 cites W2008075048 @default.
• W2786249979 cites W2008808088 @default.
• W2786249979 cites W2010775383 @default.
• W2786249979 cites W2027717778 @default.
• W2786249979 cites W2032804919 @default.
• W2786249979 cites W2036821913 @default.
• W2786249979 cites W2039917092 @default.
• W2786249979 cites W2041659526 @default.
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• W2786249979 cites W2047993346 @default.
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• W2786249979 cites W2050748273 @default.
• W2786249979 cites W2057742112 @default.
• W2786249979 cites W2059467538 @default.
• W2786249979 cites W2060029188 @default.
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• W2786249979 cites W2065375397 @default.
• W2786249979 cites W2068694119 @default.
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• W2786249979 cites W2076269475 @default.
• W2786249979 cites W2079284567 @default.
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• W2786249979 cites W2121287580 @default.
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• W2786249979 cites W2275900200 @default.
• W2786249979 cites W2313777562 @default.
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• W2786249979 cites W2328313234 @default.
• W2786249979 cites W2335093845 @default.
• W2786249979 cites W2346647512 @default.
• W2786249979 cites W2400468982 @default.
• W2786249979 cites W2417154002 @default.
• W2786249979 cites W2468944904 @default.
• W2786249979 cites W2608501046 @default.
• W2786249979 cites W2611664377 @default.
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• W2786249979 cites W2620098252 @default.
• W2786249979 cites W2623831325 @default.
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• W2786249979 doi "https://doi.org/10.1021/acs.biochem.7b01096" @default.
• W2786249979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5879137" @default.
• W2786249979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29389111" @default.
• W2786249979 hasPublicationYear "2018" @default.
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