FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786266231> ?p ?o ?g. }

• W2786266231 abstract "Introduction: A reproducible large animal model for abdominal aortic aneurysms (AAAs) does not exist. This study sought to develop a large animal AAA model in swine using β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, an enzyme responsible for collagen cross-linking. We hypothesized that elastase/collagenase perfusion and balloon dilatation in combination with BAPN administration would result in AAA formation. Methods: Uncastrated Yorkshire male swine were fed BAPN (0.12g/kg) daily for one week prior to surgery and continued throughout the experiment. After anesthesia, the aorta was exposed from the renal arteries to the aortic bifurcation. The infrarenal aorta was cannulated via the caudal mesenteric artery and an aortic angioplasty was performed to dilate the aorta to 200% of its original diameter. Next, a 30 mL solution consisting of 500 units of elastase and 8,000 units of Type I collagenase was perfused into the infrarenal aorta for 10 minutes. This solution was also then topically applied for 10 minutes. The abdomen was irrigated and closed. Antibiotics and analgesic medications were administered. Results: BAPN-fed swine sacrificed at 28 days (n=5) had a 101% increase in infrarenal aorta diameter compared with day 0 (p=0.008). Swine (n=4) sacrificed at 7 and 14 days showed an increase of 114 and 75%, respectively. Histologically on day 28, collagen decreased by 20% and smooth muscle cell expression decreased by 40% (p=0.0001) in the aortic wall compared with control suprarenal aorta. Infrarenal aortas also showed a strong predilection for M1-polarized macrophages (MCP-1 positive staining, p=0.0165) compared with M2 macrophages (Arg-1 positive staining). MMP2 activity by zymography (p=0.0127) and IL-18 by array was also significantly increased (p=0.0202) on day 28 in the infrarenal AAA. Conclusions: Compared with previous large animal AAA models, this model using conventional techniques including balloon dilatation, elastase/collagenase perfusion, in addition to oral BAPN led to robust AAA with similar molecular and histologic changes to those seen in human AAA. This novel swine AAA model may serve as a much-needed link that will allow for the progression of studies from rodents to humans." @default.
• W2786266231 created "2018-02-23" @default.
• W2786266231 creator A5000321475 @default.
• W2786266231 creator A5007754500 @default.
• W2786266231 creator A5010943367 @default.
• W2786266231 creator A5030091905 @default.
• W2786266231 creator A5031059930 @default.
• W2786266231 creator A5034367622 @default.
• W2786266231 creator A5035277839 @default.
• W2786266231 creator A5056652743 @default.
• W2786266231 creator A5058111361 @default.
• W2786266231 creator A5081748584 @default.
• W2786266231 creator A5082409406 @default.
• W2786266231 date "2017-05-01" @default.
• W2786266231 modified "2023-09-24" @default.
• W2786266231 title "Abstract 102: A Novel Swine Model of Infrarenal Abdominal Aortic Aneurysm" @default.
• W2786266231 doi "https://doi.org/10.1161/atvb.37.suppl_1.102" @default.
• W2786266231 hasPublicationYear "2017" @default.
• W2786266231 type Work @default.
• W2786266231 sameAs 2786266231 @default.
• W2786266231 citedByCount "0" @default.
• W2786266231 crossrefType "journal-article" @default.
• W2786266231 hasAuthorship W2786266231A5000321475 @default.
• W2786266231 hasAuthorship W2786266231A5007754500 @default.
• W2786266231 hasAuthorship W2786266231A5010943367 @default.
• W2786266231 hasAuthorship W2786266231A5030091905 @default.
• W2786266231 hasAuthorship W2786266231A5031059930 @default.
• W2786266231 hasAuthorship W2786266231A5034367622 @default.
• W2786266231 hasAuthorship W2786266231A5035277839 @default.
• W2786266231 hasAuthorship W2786266231A5056652743 @default.
• W2786266231 hasAuthorship W2786266231A5058111361 @default.
• W2786266231 hasAuthorship W2786266231A5081748584 @default.
• W2786266231 hasAuthorship W2786266231A5082409406 @default.
• W2786266231 hasConcept C126322002 @default.
• W2786266231 hasConcept C126894567 @default.
• W2786266231 hasConcept C141071460 @default.
• W2786266231 hasConcept C142724271 @default.
• W2786266231 hasConcept C146957229 @default.
• W2786266231 hasConcept C164705383 @default.
• W2786266231 hasConcept C181199279 @default.
• W2786266231 hasConcept C193143273 @default.
• W2786266231 hasConcept C2776098176 @default.
• W2786266231 hasConcept C2777323849 @default.
• W2786266231 hasConcept C2778394429 @default.
• W2786266231 hasConcept C2779869378 @default.
• W2786266231 hasConcept C2779980429 @default.
• W2786266231 hasConcept C2779993416 @default.
• W2786266231 hasConcept C2780520971 @default.
• W2786266231 hasConcept C2781044401 @default.
• W2786266231 hasConcept C2781046184 @default.
• W2786266231 hasConcept C55493867 @default.
• W2786266231 hasConcept C71924100 @default.
• W2786266231 hasConcept C86803240 @default.
• W2786266231 hasConceptScore W2786266231C126322002 @default.
• W2786266231 hasConceptScore W2786266231C126894567 @default.
• W2786266231 hasConceptScore W2786266231C141071460 @default.
• W2786266231 hasConceptScore W2786266231C142724271 @default.
• W2786266231 hasConceptScore W2786266231C146957229 @default.
• W2786266231 hasConceptScore W2786266231C164705383 @default.
• W2786266231 hasConceptScore W2786266231C181199279 @default.
• W2786266231 hasConceptScore W2786266231C193143273 @default.
• W2786266231 hasConceptScore W2786266231C2776098176 @default.
• W2786266231 hasConceptScore W2786266231C2777323849 @default.
• W2786266231 hasConceptScore W2786266231C2778394429 @default.
• W2786266231 hasConceptScore W2786266231C2779869378 @default.
• W2786266231 hasConceptScore W2786266231C2779980429 @default.
• W2786266231 hasConceptScore W2786266231C2779993416 @default.
• W2786266231 hasConceptScore W2786266231C2780520971 @default.
• W2786266231 hasConceptScore W2786266231C2781044401 @default.
• W2786266231 hasConceptScore W2786266231C2781046184 @default.
• W2786266231 hasConceptScore W2786266231C55493867 @default.
• W2786266231 hasConceptScore W2786266231C71924100 @default.
• W2786266231 hasConceptScore W2786266231C86803240 @default.
• W2786266231 hasIssue "suppl_1" @default.
• W2786266231 hasLocation W27862662311 @default.
• W2786266231 hasOpenAccess W2786266231 @default.
• W2786266231 hasPrimaryLocation W27862662311 @default.
• W2786266231 hasRelatedWork W1989486705 @default.
• W2786266231 hasRelatedWork W1992889788 @default.
• W2786266231 hasRelatedWork W2034516712 @default.
• W2786266231 hasRelatedWork W2057259121 @default.
• W2786266231 hasRelatedWork W2064868286 @default.
• W2786266231 hasRelatedWork W2064922556 @default.
• W2786266231 hasRelatedWork W2087544591 @default.
• W2786266231 hasRelatedWork W2102653072 @default.
• W2786266231 hasRelatedWork W2123518040 @default.
• W2786266231 hasRelatedWork W2351914712 @default.
• W2786266231 hasRelatedWork W2378523487 @default.
• W2786266231 hasRelatedWork W2387383997 @default.
• W2786266231 hasRelatedWork W2593128989 @default.
• W2786266231 hasRelatedWork W2776810232 @default.
• W2786266231 hasRelatedWork W2807878618 @default.
• W2786266231 hasRelatedWork W2954440794 @default.
• W2786266231 hasRelatedWork W3010877646 @default.
• W2786266231 hasRelatedWork W3019096900 @default.
• W2786266231 hasRelatedWork W3186475418 @default.
• W2786266231 hasRelatedWork W3212252685 @default.
• W2786266231 hasVolume "37" @default.
• W2786266231 isParatext "false" @default.
• W2786266231 isRetracted "false" @default.

• next