Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786346055> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2786346055 endingPage "3768" @default.
- W2786346055 startingPage "3768" @default.
- W2786346055 abstract "A new series of 2-pyridone derivatives (A1-A6) were synthesized by various substitution and their structures were confirmed by spectral and elemental analyses. The cytotoxic activities of the newly synthesized compounds were docked against JNKs (2WAJ Transferase). JNKs pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. The molecular docking study was used for confirming their interaction with c-Jun N-terminal kinases (JNKs). Through in silico molecular docking study, the result showed that all synthesized derivatives (A1-A6) have low binding energy (Table 1) and have good affinity toward their active pocket thus the synthesized derivatives were considered as good JNKs inhibitors. This will help to inhibit the outgrowth of cell and can be act as good anti cancer agents." @default.
- W2786346055 created "2018-02-23" @default.
- W2786346055 creator A5050031621 @default.
- W2786346055 creator A5061520779 @default.
- W2786346055 creator A5080090742 @default.
- W2786346055 date "2017-01-01" @default.
- W2786346055 modified "2023-10-18" @default.
- W2786346055 title "Design, Synthesis and Characterization of 2-pyridone Derivatives as C-Jun N-terminal Kinases (JNKs) Signaling Pathway Inhibitors" @default.
- W2786346055 doi "https://doi.org/10.5958/0974-360x.2017.00684.9" @default.
- W2786346055 hasPublicationYear "2017" @default.
- W2786346055 type Work @default.
- W2786346055 sameAs 2786346055 @default.
- W2786346055 citedByCount "0" @default.
- W2786346055 crossrefType "journal-article" @default.
- W2786346055 hasAuthorship W2786346055A5050031621 @default.
- W2786346055 hasAuthorship W2786346055A5061520779 @default.
- W2786346055 hasAuthorship W2786346055A5080090742 @default.
- W2786346055 hasConcept C104317684 @default.
- W2786346055 hasConcept C184235292 @default.
- W2786346055 hasConcept C2779087070 @default.
- W2786346055 hasConcept C2779664074 @default.
- W2786346055 hasConcept C31258907 @default.
- W2786346055 hasConcept C41008148 @default.
- W2786346055 hasConcept C55493867 @default.
- W2786346055 hasConcept C86339819 @default.
- W2786346055 hasConcept C86803240 @default.
- W2786346055 hasConcept C95444343 @default.
- W2786346055 hasConceptScore W2786346055C104317684 @default.
- W2786346055 hasConceptScore W2786346055C184235292 @default.
- W2786346055 hasConceptScore W2786346055C2779087070 @default.
- W2786346055 hasConceptScore W2786346055C2779664074 @default.
- W2786346055 hasConceptScore W2786346055C31258907 @default.
- W2786346055 hasConceptScore W2786346055C41008148 @default.
- W2786346055 hasConceptScore W2786346055C55493867 @default.
- W2786346055 hasConceptScore W2786346055C86339819 @default.
- W2786346055 hasConceptScore W2786346055C86803240 @default.
- W2786346055 hasConceptScore W2786346055C95444343 @default.
- W2786346055 hasIssue "11" @default.
- W2786346055 hasLocation W27863460551 @default.
- W2786346055 hasOpenAccess W2786346055 @default.
- W2786346055 hasPrimaryLocation W27863460551 @default.
- W2786346055 hasRelatedWork W1972145919 @default.
- W2786346055 hasRelatedWork W2079989779 @default.
- W2786346055 hasRelatedWork W2120287690 @default.
- W2786346055 hasRelatedWork W2150563383 @default.
- W2786346055 hasRelatedWork W2162778162 @default.
- W2786346055 hasRelatedWork W2916348895 @default.
- W2786346055 hasRelatedWork W4247986854 @default.
- W2786346055 hasRelatedWork W4213459473 @default.
- W2786346055 hasRelatedWork W4214778897 @default.
- W2786346055 hasRelatedWork W4214955010 @default.
- W2786346055 hasVolume "10" @default.
- W2786346055 isParatext "false" @default.
- W2786346055 isRetracted "false" @default.
- W2786346055 magId "2786346055" @default.
- W2786346055 workType "article" @default.