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• W2786453908 abstract "NK cell function is calibrated through a process called ‘education’. The reactive potential of each NK cell is counterbalanced by its sensitivity to inhibition by self-MHC class I molecules. Immunogenetic variability confers different education programs between individual subjects, leading to variable sensitivity to activating and inhibitory input. Differences in NK cell education, which can be predicted by NK immunogenetics, impact susceptibility and resistance to specific disease phenotypes. The functional capacities of natural killer (NK) cells differ within and between individuals, reflecting considerable genetic variation. ‘Licensing/arming’, ‘disarming’, and ‘tuning’ are models that have been proposed to explain how interactions between MHC class I molecules and their cognate inhibitory receptors – Ly49 in mice and KIR in humans – ‘educate’ NK cells for variable reactivity and sensitivity to inhibition. In this review we discuss recent progress toward understanding the genetic, epigenetic, and molecular features that titrate NK effector function and inhibition, and the impact of variable NK cell education on human health and disease. The functional capacities of natural killer (NK) cells differ within and between individuals, reflecting considerable genetic variation. ‘Licensing/arming’, ‘disarming’, and ‘tuning’ are models that have been proposed to explain how interactions between MHC class I molecules and their cognate inhibitory receptors – Ly49 in mice and KIR in humans – ‘educate’ NK cells for variable reactivity and sensitivity to inhibition. In this review we discuss recent progress toward understanding the genetic, epigenetic, and molecular features that titrate NK effector function and inhibition, and the impact of variable NK cell education on human health and disease. memory-like, self-renewing natural killer (NK) cells that are established after exposure to an antigen or pathogen and that exhibit inhibitory receptors for self-MHC ligands and respond to rechallenge with homologous antigen stimulation. a model for NK cell education proposing that all cells are initially responsive, but lose responsiveness as a result of chronic activation unless rescued through inhibition by binding to self-MHC. the process through which an NK cell is programmed for reactivity, calibrated by its ability to be inhibited by self proteins, principally HLA or MHC class I molecules. the set of MHC molecules expressed in humans. a model for NK cell education proposing that NK cells sensitive to inhibition by self molecules will activate a program through which they are potentiated for reactivity. a set of highly polymorphic, polygenic cell-surface proteins exhibited in all vertebrates. Class I MHC proteins engage NK cells for education and define ‘self’. In mice, MHC class I are also referred to as H-2 molecules. a model for NK cell education proposing that the magnitude of NK cell reactive potential is quantitatively counterbalanced by inhibitory interactions between NK and healthy cells." @default.
• W2786453908 created "2018-02-23" @default.
• W2786453908 creator A5056539557 @default.
• W2786453908 creator A5088189511 @default.
• W2786453908 date "2018-03-01" @default.
• W2786453908 modified "2023-10-17" @default.
• W2786453908 title "Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned" @default.
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