Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786508500> ?p ?o ?g. }
- W2786508500 startingPage "242941" @default.
- W2786508500 abstract "The Glucose Transporter 4 (GLUT4) in muscle and adipose tissue mediates post-prandial blood glucose clearance by insulin-stimulated GLUT4 translocation to the cell surface from an intracellular GLUT4 storage compartment (GSC). Deregulation of this process establishes insulin resistance and contributes to pathogenesis of type-2 diabetes (T2D). Endocytic pathways targeting GLUT4 to the GSC after insulin-mediated release have been defined extensively in rodent models. Here we map the biosynthetic trafficking pathway leading to initial GSC formation, which is less characterised, and differs between humans and rodents. In human muscle and adipocytes, GSC formation involves the non-canonical isoform of clathrin, CHC22, which does not mediate endocytosis and accumulates at sites of GLUT4 sequestration during insulin resistance. Mice have lost the CLTCL1 gene encoding CHC22, and use conventional CHC17 clathrin for GSC formation by endocytic pathways that do not replace CHC22 function in human GSC formation. Here we report that CHC22 controls GLUT4 transport from the ER-to-Golgi intermediate compartment (ERGIC) in an unconventional secretory pathway, bypassing the Golgi, to form the human GSC. This specialized route for human GLUT4 membrane traffic has relevance for understanding insulin resistance." @default.
- W2786508500 created "2018-02-23" @default.
- W2786508500 creator A5005487615 @default.
- W2786508500 creator A5026896911 @default.
- W2786508500 creator A5028720131 @default.
- W2786508500 creator A5030196766 @default.
- W2786508500 creator A5030757228 @default.
- W2786508500 creator A5033940715 @default.
- W2786508500 creator A5072897813 @default.
- W2786508500 creator A5084806589 @default.
- W2786508500 creator A5086047033 @default.
- W2786508500 date "2018-01-04" @default.
- W2786508500 modified "2023-09-26" @default.
- W2786508500 title "CHC22 Clathrin Diverts GLUT4 from the ER-to-Golgi Intermediate Compartment for Intracellular Sequestration" @default.
- W2786508500 cites W1940760798 @default.
- W2786508500 cites W1967701730 @default.
- W2786508500 cites W1975964692 @default.
- W2786508500 cites W1981594750 @default.
- W2786508500 cites W1981940952 @default.
- W2786508500 cites W1991410135 @default.
- W2786508500 cites W1992064660 @default.
- W2786508500 cites W1997957892 @default.
- W2786508500 cites W2003861253 @default.
- W2786508500 cites W2005753856 @default.
- W2786508500 cites W2009181620 @default.
- W2786508500 cites W2011599911 @default.
- W2786508500 cites W2026904918 @default.
- W2786508500 cites W2038750623 @default.
- W2786508500 cites W2043835841 @default.
- W2786508500 cites W2048251935 @default.
- W2786508500 cites W2051083711 @default.
- W2786508500 cites W2051399235 @default.
- W2786508500 cites W2061849844 @default.
- W2786508500 cites W2061990118 @default.
- W2786508500 cites W2068891266 @default.
- W2786508500 cites W2094663320 @default.
- W2786508500 cites W2096466814 @default.
- W2786508500 cites W2098974443 @default.
- W2786508500 cites W2118130192 @default.
- W2786508500 cites W2125711274 @default.
- W2786508500 cites W2127767424 @default.
- W2786508500 cites W2130965044 @default.
- W2786508500 cites W2132099317 @default.
- W2786508500 cites W2133244586 @default.
- W2786508500 cites W2136036129 @default.
- W2786508500 cites W2136755280 @default.
- W2786508500 cites W2139059560 @default.
- W2786508500 cites W2140191008 @default.
- W2786508500 cites W2144120461 @default.
- W2786508500 cites W2155802517 @default.
- W2786508500 cites W2160300109 @default.
- W2786508500 cites W2164778663 @default.
- W2786508500 cites W2165334283 @default.
- W2786508500 cites W2233026563 @default.
- W2786508500 cites W2471596662 @default.
- W2786508500 cites W26034423 @default.
- W2786508500 cites W990212049 @default.
- W2786508500 hasPublicationYear "2018" @default.
- W2786508500 type Work @default.
- W2786508500 sameAs 2786508500 @default.
- W2786508500 citedByCount "2" @default.
- W2786508500 countsByYear W27865085002018 @default.
- W2786508500 crossrefType "posted-content" @default.
- W2786508500 hasAuthorship W2786508500A5005487615 @default.
- W2786508500 hasAuthorship W2786508500A5026896911 @default.
- W2786508500 hasAuthorship W2786508500A5028720131 @default.
- W2786508500 hasAuthorship W2786508500A5030196766 @default.
- W2786508500 hasAuthorship W2786508500A5030757228 @default.
- W2786508500 hasAuthorship W2786508500A5033940715 @default.
- W2786508500 hasAuthorship W2786508500A5072897813 @default.
- W2786508500 hasAuthorship W2786508500A5084806589 @default.
- W2786508500 hasAuthorship W2786508500A5086047033 @default.
- W2786508500 hasBestOaLocation W27865085001 @default.
- W2786508500 hasConcept C119062480 @default.
- W2786508500 hasConcept C134018914 @default.
- W2786508500 hasConcept C1491633281 @default.
- W2786508500 hasConcept C158617107 @default.
- W2786508500 hasConcept C161573976 @default.
- W2786508500 hasConcept C2776188179 @default.
- W2786508500 hasConcept C2777391703 @default.
- W2786508500 hasConcept C2779306644 @default.
- W2786508500 hasConcept C28005876 @default.
- W2786508500 hasConcept C55493867 @default.
- W2786508500 hasConcept C63162447 @default.
- W2786508500 hasConcept C79747257 @default.
- W2786508500 hasConcept C79879829 @default.
- W2786508500 hasConcept C86803240 @default.
- W2786508500 hasConcept C95444343 @default.
- W2786508500 hasConceptScore W2786508500C119062480 @default.
- W2786508500 hasConceptScore W2786508500C134018914 @default.
- W2786508500 hasConceptScore W2786508500C1491633281 @default.
- W2786508500 hasConceptScore W2786508500C158617107 @default.
- W2786508500 hasConceptScore W2786508500C161573976 @default.
- W2786508500 hasConceptScore W2786508500C2776188179 @default.
- W2786508500 hasConceptScore W2786508500C2777391703 @default.
- W2786508500 hasConceptScore W2786508500C2779306644 @default.
- W2786508500 hasConceptScore W2786508500C28005876 @default.
- W2786508500 hasConceptScore W2786508500C55493867 @default.
- W2786508500 hasConceptScore W2786508500C63162447 @default.