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- W2786536843 abstract "In this study the spatial drug concentration development within skin over time is investigated focusing especially on effects of lateral drug diffusion and drug depot formation. The process is characterized using an artificial skin construct (ASC) and native human skin.For this an experimental set up provoking a larger influence of lateral diffusion was developed. Diffusion experiments with ASC, planed human skin (PHS) and full thickness human skin (FHS) were carried out using the ibuprofen containing formulation Ibutop Creme, Ibutop + 5 % urea and Ibutop + 5 % DMSO for several time points.It was shown that the spatial concentration development in all skin types follows the same principal pattern characterized by the two phases of drug accumulation followed by redistribution. The observed concentration maximum for the central skin segment is explained by the lag time for the effective lateral diffusion leading to a three dimensional drainage compared to the one dimensional vertical diffusion during the accumulation phase. The use of the additional permeation enhancers mainly lead to larger amounts in the skin but not to a relatively greater lateral diffusion.The time frame for the concentration profile development as observed in the human skins is largely reduced in ASC due to the lower permeation barrier. Still the very close resemblance between these two skin types is observed for the individual skin segment concentration as well as for the total drug amount in the skin with a similar differentiation between enhancer containing formulation to Ibutop alone. This high similarity might mainly be based on the very good comparability of the relative permeation enhancing effect of the respective formulations.Since the process within ASC and human skin, responsible for lateral diffusion and thus depot building, were shown to be highly similar the use of ASC for studies on drug diffusion in and through skin is reasonable." @default.
- W2786536843 created "2018-02-23" @default.
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- W2786536843 date "2010-11-04" @default.
- W2786536843 modified "2023-09-27" @default.
- W2786536843 title "Investigation of lateral diffusion as process for drug depot building in an artificial skin construct and human skin" @default.
- W2786536843 hasPublicationYear "2010" @default.
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