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• W2786639632 abstract "This chapter discusses the effects of both endogenous and synthetic peptides in the context of use as AT 2 R agonists. Historically, ­peptides have often been disregarded for therapeutic development due to their poor in vivo stability and lack of receptor subtype selectivity. However, recent developments in drug delivery technologies and advanced knowledge of chemical modifications to alter ­pharmacological characteristics have reinvigorated the field of peptide therapeutics. Indeed, peptides have been frequently utilized as the basis of drug design due to beneficial properties such as relatively cheap and simple synthesis, high-affinity binding at cognate receptors, and potential for further chemical additions and substitutions. Moreover, considering the still unresolved role of AT 2 R function in many contexts, ­peptide agonists are also likely to remain invaluable experimental tools for the field of AT 2 R research well into the future." @default.
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• W2786639632 date "2015-01-01" @default.
• W2786639632 modified "2023-10-17" @default.
• W2786639632 title "Angiotensin-Based Peptides as AT2R Agonists" @default.
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• W2786639632 doi "https://doi.org/10.1016/b978-0-12-801364-9.00019-5" @default.
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