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- W2786692211 abstract "Most well-characterized enhancers are deeply conserved. In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved. To better understand conservation of enhancer activity, we used a comparative genomics approach that integrates temporal expression and epigenetic profiles in an innate immune system. We found that gene expression programs diverge among mildly induced genes, while being highly conserved for strongly induced genes. The fraction of conserved enhancers varies greatly across gene expression programs, with induced genes and early-response genes, in particular, being regulated by a higher fraction of conserved enhancers. Clustering of conserved accessible DNA sequences within enhancers resulted in over 60 sequence motifs including motifs for known factors, as well as many with unknown function. We further show that the number of instances of these motifs is a strong predictor of the responsiveness of a gene to pathogen detection." @default.
- W2786692211 created "2018-02-23" @default.
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- W2786692211 date "2018-03-01" @default.
- W2786692211 modified "2023-10-16" @default.
- W2786692211 title "Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon" @default.
- W2786692211 cites W1497894656 @default.
- W2786692211 cites W1531821806 @default.
- W2786692211 cites W1560571961 @default.
- W2786692211 cites W1636205509 @default.
- W2786692211 cites W1847732278 @default.
- W2786692211 cites W1965409500 @default.
- W2786692211 cites W1965425724 @default.
- W2786692211 cites W1971578941 @default.
- W2786692211 cites W1975929837 @default.
- W2786692211 cites W1987301268 @default.
- W2786692211 cites W1988871238 @default.
- W2786692211 cites W1991543373 @default.
- W2786692211 cites W1996760543 @default.
- W2786692211 cites W1997767982 @default.
- W2786692211 cites W1998000745 @default.
- W2786692211 cites W1998141315 @default.
- W2786692211 cites W1999574084 @default.
- W2786692211 cites W2000609514 @default.
- W2786692211 cites W2001770641 @default.
- W2786692211 cites W2006378142 @default.
- W2786692211 cites W2007222211 @default.
- W2786692211 cites W2007244502 @default.
- W2786692211 cites W2012071760 @default.
- W2786692211 cites W2016015848 @default.
- W2786692211 cites W2016953583 @default.
- W2786692211 cites W2021168471 @default.
- W2786692211 cites W2021341670 @default.
- W2786692211 cites W2021373833 @default.
- W2786692211 cites W2033169664 @default.
- W2786692211 cites W2035618305 @default.
- W2786692211 cites W2040034523 @default.
- W2786692211 cites W2040909468 @default.
- W2786692211 cites W2042160423 @default.
- W2786692211 cites W2063669037 @default.
- W2786692211 cites W2065103652 @default.
- W2786692211 cites W2083394029 @default.
- W2786692211 cites W2088069070 @default.
- W2786692211 cites W2090602346 @default.
- W2786692211 cites W2092250990 @default.
- W2786692211 cites W2093263524 @default.
- W2786692211 cites W2095005830 @default.
- W2786692211 cites W2095903180 @default.
- W2786692211 cites W2096525273 @default.
- W2786692211 cites W2098188064 @default.
- W2786692211 cites W2102619694 @default.
- W2786692211 cites W2103777723 @default.
- W2786692211 cites W2105598902 @default.
- W2786692211 cites W2106296224 @default.
- W2786692211 cites W2107665951 @default.
- W2786692211 cites W2107922733 @default.
- W2786692211 cites W2108234281 @default.
- W2786692211 cites W2109963121 @default.
- W2786692211 cites W2117757143 @default.
- W2786692211 cites W2118608526 @default.
- W2786692211 cites W2127799088 @default.
- W2786692211 cites W2131271579 @default.
- W2786692211 cites W2131487299 @default.
- W2786692211 cites W2131632095 @default.
- W2786692211 cites W2132914434 @default.
- W2786692211 cites W2138897185 @default.
- W2786692211 cites W2140538490 @default.
- W2786692211 cites W2140952049 @default.
- W2786692211 cites W2142735201 @default.
- W2786692211 cites W2145144631 @default.
- W2786692211 cites W2149662811 @default.
- W2786692211 cites W2151754128 @default.
- W2786692211 cites W2152851821 @default.
- W2786692211 cites W2154746182 @default.
- W2786692211 cites W2155845523 @default.
- W2786692211 cites W2160953907 @default.
- W2786692211 cites W2161682414 @default.
- W2786692211 cites W2166251028 @default.
- W2786692211 cites W2168602111 @default.
- W2786692211 cites W2168631252 @default.
- W2786692211 cites W2169353806 @default.
- W2786692211 cites W2170551349 @default.
- W2786692211 cites W2171808845 @default.
- W2786692211 cites W2179308868 @default.
- W2786692211 cites W2179438025 @default.
- W2786692211 cites W2194390873 @default.