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- W27867551 abstract "1. ABSTRACT The effects of ATP and arachidonic acid on junctional conductance (Gj) were studied in Novikoff hepatoma cells, while monitoring either [Ca2+]i, with fura-2, or both membrane and junctional currents, with double whole-cell (DWCC) or double perforated patch clamp (DPPC). ATP (100 μM) increased [Ca2+]i to 400-1200 nM and in most cells decreased Gj by 30-40%. Simultaneously, an outward current developed, with a reversal potential of −80 mV at normal [K+]o that became 0 at 140 mM [K+]o, indicating that it is a Ca2+-activated K-current. Current peaks coincided with Gj minima, indicating that both phenomena result from an increase in [Ca2+]i. Arachidonic acid (AA, 20 μM, 20 s) had similar effects on [Ca2+]i and Gj. Internal BAPTA prevented Gj changes, suggesting Ca2+ dependence, but long exposures (20 μM AA, 1 min) caused uncoupling even with internal BAPTA, indicating that AA has both a Ca2+ mediated and a Ca2+ independent effect on coupling. However, Ca2+ dependent uncoupling had a much faster time course. BAPTA did not prevent uncoupling by oleic acid (OA) or halothane, suggesting that they act in Ca2+ independent way." @default.
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- W27867551 date "1995-01-01" @default.
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- W27867551 title "Calcium participation in ATP and arachidonic acid but not in oleic acid and halothane induced gating of gap junctions in Novikoff cells" @default.
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- W27867551 doi "https://doi.org/10.1016/b978-0-444-81929-1.50093-9" @default.
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