Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786756830> ?p ?o ?g. }
- W2786756830 endingPage "533" @default.
- W2786756830 startingPage "524" @default.
- W2786756830 abstract "A dual-purpose strategy aimed at enhancing the binding affinity for microtubules and improving the water solubility of docetaxel led to the design and synthesis of a series of C-2- and C-3′-modified analogues. Both aims were realized when the C-3′ phenyl group present in docetaxel was replaced with a propargyl alcohol. The resulting compound, 3f, was able to overcome drug resistance in cultured P-gp-overexpressing tumor cells and showed greater activity than docetaxel against drug-resistant A2780/AD ovarian cancer xenografts in mice. In addition, the considerably lower hydrophobicity of 3f relative to both docetaxel and paclitaxel led to better aqueous solubility. A molecular model of tubulin-bound 3f revealed novel hydrogen-bonding interactions between the propargyl alcohol and the polar environment provided by the side chains of Ser236, Glu27, and Arg320." @default.
- W2786756830 created "2018-02-23" @default.
- W2786756830 creator A5025336058 @default.
- W2786756830 creator A5026094138 @default.
- W2786756830 creator A5036467819 @default.
- W2786756830 creator A5039360390 @default.
- W2786756830 creator A5042787673 @default.
- W2786756830 creator A5043136617 @default.
- W2786756830 creator A5048905988 @default.
- W2786756830 creator A5057856773 @default.
- W2786756830 creator A5066158393 @default.
- W2786756830 creator A5072447114 @default.
- W2786756830 creator A5082213642 @default.
- W2786756830 creator A5090120974 @default.
- W2786756830 date "2018-01-23" @default.
- W2786756830 modified "2023-09-22" @default.
- W2786756830 title "A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility" @default.
- W2786756830 cites W1964245683 @default.
- W2786756830 cites W1965919622 @default.
- W2786756830 cites W1978728170 @default.
- W2786756830 cites W201386325 @default.
- W2786756830 cites W2027087637 @default.
- W2786756830 cites W2041157986 @default.
- W2786756830 cites W2041434932 @default.
- W2786756830 cites W2041920169 @default.
- W2786756830 cites W2043782165 @default.
- W2786756830 cites W2044647958 @default.
- W2786756830 cites W2047845061 @default.
- W2786756830 cites W2051905300 @default.
- W2786756830 cites W2052002840 @default.
- W2786756830 cites W2055397209 @default.
- W2786756830 cites W2058997498 @default.
- W2786756830 cites W2063770164 @default.
- W2786756830 cites W2066597628 @default.
- W2786756830 cites W2083482813 @default.
- W2786756830 cites W2092800219 @default.
- W2786756830 cites W2106140689 @default.
- W2786756830 cites W2107410530 @default.
- W2786756830 cites W2127684498 @default.
- W2786756830 cites W2134104912 @default.
- W2786756830 cites W2136447069 @default.
- W2786756830 cites W2144564583 @default.
- W2786756830 cites W2147571602 @default.
- W2786756830 cites W2156495637 @default.
- W2786756830 cites W2157800681 @default.
- W2786756830 cites W2158066095 @default.
- W2786756830 cites W2159672956 @default.
- W2786756830 cites W2162785195 @default.
- W2786756830 cites W2164153400 @default.
- W2786756830 cites W2167032192 @default.
- W2786756830 cites W2168240189 @default.
- W2786756830 cites W2189686546 @default.
- W2786756830 cites W2326124692 @default.
- W2786756830 cites W2404280981 @default.
- W2786756830 cites W2566284109 @default.
- W2786756830 cites W2620782252 @default.
- W2786756830 cites W2624137165 @default.
- W2786756830 cites W2744422984 @default.
- W2786756830 doi "https://doi.org/10.1021/acs.jnatprod.7b00857" @default.
- W2786756830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29359935" @default.
- W2786756830 hasPublicationYear "2018" @default.
- W2786756830 type Work @default.
- W2786756830 sameAs 2786756830 @default.
- W2786756830 citedByCount "38" @default.
- W2786756830 countsByYear W27867568302018 @default.
- W2786756830 countsByYear W27867568302019 @default.
- W2786756830 countsByYear W27867568302020 @default.
- W2786756830 countsByYear W27867568302021 @default.
- W2786756830 countsByYear W27867568302022 @default.
- W2786756830 countsByYear W27867568302023 @default.
- W2786756830 crossrefType "journal-article" @default.
- W2786756830 hasAuthorship W2786756830A5025336058 @default.
- W2786756830 hasAuthorship W2786756830A5026094138 @default.
- W2786756830 hasAuthorship W2786756830A5036467819 @default.
- W2786756830 hasAuthorship W2786756830A5039360390 @default.
- W2786756830 hasAuthorship W2786756830A5042787673 @default.
- W2786756830 hasAuthorship W2786756830A5043136617 @default.
- W2786756830 hasAuthorship W2786756830A5048905988 @default.
- W2786756830 hasAuthorship W2786756830A5057856773 @default.
- W2786756830 hasAuthorship W2786756830A5066158393 @default.
- W2786756830 hasAuthorship W2786756830A5072447114 @default.
- W2786756830 hasAuthorship W2786756830A5082213642 @default.
- W2786756830 hasAuthorship W2786756830A5090120974 @default.
- W2786756830 hasConcept C121608353 @default.
- W2786756830 hasConcept C126322002 @default.
- W2786756830 hasConcept C155574463 @default.
- W2786756830 hasConcept C161790260 @default.
- W2786756830 hasConcept C178790620 @default.
- W2786756830 hasConcept C184651966 @default.
- W2786756830 hasConcept C185592680 @default.
- W2786756830 hasConcept C20418707 @default.
- W2786756830 hasConcept C21951064 @default.
- W2786756830 hasConcept C2777292972 @default.
- W2786756830 hasConcept C2777731188 @default.
- W2786756830 hasConcept C2780437523 @default.
- W2786756830 hasConcept C2781066024 @default.
- W2786756830 hasConcept C2781190966 @default.
- W2786756830 hasConcept C71240020 @default.