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• W2786768191 abstract "Background: Macrophages are cells of the innate immune system that populate every organ. They are required for defense against invading pathogens and tissue repair but also for maintenance of tissue homeostasis and iron homeostasis. Aim: The aim of this study was to understand whether heme oxygenase (HO) and nitric oxide synthase (NOS) contribute to the regulation of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX) activity and phagocytosis, two key components of macrophage function. Methods: The study was carried out using resting J774A.1 macrophages treated with hemin or vehicle. Activity of NOS, HO, or NOX was inhibited using specific inhibitors. Reactive oxygen species (ROS) formation was determined by Amplex® red assay, phagocytosis was measured using fluorescein isothiocyanate labeled bacteria. Additionally, we analyzed the fate of the intracellular heme by using electron spin resonance. Results: We show that both enzymes NOS and HO are essential for phagocytic activity of macrophages. NOS does not directly affect phagocytosis, but stimulates NOX activity via nitric oxide triggered ROS production of mitochondria. Treatment of macrophages with hemin results in intracellular accumulation of ferrous heme and an inhibition of phagocytosis. In contrast to NOS, HO products, including carbon monoxide, neither clearly affect NOX activity, nor phagocytosis, but phagocytosis is accelerated by HO mediated degradation of heme. Conclusion: Both enzymes contribute to the bactericidal activity of macrophages independently, by controlling different pathways." @default.
• W2786768191 created "2018-02-23" @default.
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• W2786768191 date "2018-01-22" @default.
• W2786768191 modified "2023-10-03" @default.
• W2786768191 title "Interaction between Mitochondrial Reactive Oxygen Species, Heme Oxygenase, and Nitric Oxide Synthase Stimulates Phagocytosis in Macrophages" @default.
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• W2786768191 doi "https://doi.org/10.3389/fmed.2017.00252" @default.
• W2786768191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5786743" @default.
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• W2786768191 hasPublicationYear "2018" @default.
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