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• W2786797039 abstract "The cell extracts of two cultured freshwater Nostoc spp., UIC 10279 and UIC 10366, both from the suburbs of Chicago, showed antiproliferative activity against MDA-MB-231 and MDA-MB-435 cancer cell lines. Bioassay-guided fractionation led to the isolation of five glycosylated cylindrocyclophanes, named ribocyclophanes A–E (1–5) and cylindrocyclophane D (6). The structure determination was carried out by HRESIMS and 1D and 2D NMR analyses and confirmed by single-crystal X-ray crystallography. The structures of ribocyclophanes A–E (1–5) contain a β-d-ribopyranose glycone in the rare 1C4 conformation. Among isolated compounds, ribocyclophane D (4) showed antiproliferative activity against MDA-MB-435 and MDA-MB-231 cancer cells with an IC50 value of less than 1 μM." @default.
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• W2786797039 date "2018-01-30" @default.
• W2786797039 modified "2023-09-27" @default.
• W2786797039 title "Ribocyclophanes A–E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria" @default.
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• W2786797039 doi "https://doi.org/10.1021/acs.jnatprod.7b00954" @default.
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