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- W2786854379 abstract "• A novel highly sensitive photonic crystal fiber based on the surface plasmon resonance (PCF-SPR) biosensor for the detection of the density alteration in non-physiological cells (DANCE) was investigated. • Coating sensor with gold layer on the wall of the liquid channel not only overcame manufacturing challenges for experiments, but also enhanced the sensitivity. • According to simulation results, the biosensor shows a maximum amplitude sensitivity of 2000 nm/RIU and resolution as high as 5 × 10 −5 RIU. According to the wavelength interrogation method, a maximum spectral sensitivity of 9000 nm/RIU in the sensing range between 1.33 and 1.53 is achieved, corresponding to a resolution as high as 1.11 × 10 −5 RIU for the biosensor. A highly sensitive photonic crystal fiber based on the surface plasmon resonance (PCF-SPR) biosensor for the detection of the density alteration in non-physiological cells (DANCE) is described. Human acute leukemia cells are determined by the discontinuous sucrose gradient centrifugation (DSGC) in which the cells are separated into several bands. The separated cells with different intracellular densities and refractive indexes (RI) ranging from 1.3342 to 1.3344 are distinguished in situ by means of the differential transmission spectrum. The biosensor shows a maximum amplitude sensitivity of 2000 nm/RIU and resolution as high as 5 × 10 −5 RIU. According to the wavelength interrogation method, a maximum spectral sensitivity of 9000 nm/RIU in the sensing range between 1.33 and 1.53 is achieved, corresponding to a resolution as high as 1.11 × 10 −5 RIU for the biosensor. The proposed PCF-SPR biosensor has promising application in biological and biochemical detection." @default.
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- W2786854379 date "2018-03-01" @default.
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- W2786854379 title "A high-sensitivity photonic crystal fiber (PCF) based on the surface plasmon resonance (SPR) biosensor for detection of density alteration in non-physiological cells (DANCE)" @default.
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- W2786854379 doi "https://doi.org/10.1016/j.opelre.2018.01.001" @default.
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