Matches in SemOpenAlex for { <https://semopenalex.org/work/W2786864544> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2786864544 abstract "Objective: To explore the role of AMPA receptors in SG seizures through the application of perampanel in a rat amygdala kindling model, with a comparison of the effects of sodium channel blockade by lacosamide and lamotrigine. Background: Perampanel is a non-competitive AMPA receptor antagonist approved for adjunctive treatment of partial-onset seizures, with or without SG seizures, and primary generalized tonic-clonic seizures. In Phase III trials in patients with partial-onset seizures, adjunctive perampanel conferred greater seizure control than placebo in patients with secondary generalization (Steinhoff et al. Epilepsia 2013; 54: 1481–1489). Design/Methods: On the first day, male Wistar-Kyoto rats (n=20) received increasing electrical stimulation in the basolateral amygdala until the after-discharge threshold (ADT) was reached. They then received daily stimulation at the ADT until three Racine score 5 seizures occurred consecutively. Perampanel (0.25–1.5 mg/kg), lacosamide (7.5–30 mg/kg), lamotrigine (5–20 mg/kg), or vehicle was administered intraperitoneally. Drug effects on Racine score (seizure severity) and Score 4 latency (S4L; an index of generalization rate) at the ADT stimulation were measured. Seizure severity was analyzed by Dunn’s multiple comparison tests, and S4L by Dunnett’s multiple comparison tests. Results: Perampanel conferred dose-dependent reductions in seizure severity and increases in S4L. Compared with vehicle, average Racine score was significantly reduced to 1.8 by perampanel 1.5 mg/kg ( P P P P P P Conclusions: In a rat amygdala kindling model, perampanel increased latency to SG seizures at doses that were suboptimal for reducing seizure severity, suggesting that AMPA receptors play an important role in secondary generalization. Study Supported by: Eisai Co., Ltd. Disclosure: Dr. Ting has received personal compensation for activities with Eisai as an employee. Dr. Kaneko has nothing to disclose. Dr. Ido has received personal compensation for activities with Eisai as an employee." @default.
- W2786864544 created "2018-02-23" @default.
- W2786864544 creator A5050800806 @default.
- W2786864544 creator A5080664278 @default.
- W2786864544 creator A5082915951 @default.
- W2786864544 date "2017-04-18" @default.
- W2786864544 modified "2023-09-26" @default.
- W2786864544 title "The effects of perampanel, lacosamide, and lamotrigine on secondary generalized (SG) seizures in a rat amygdala kindling model (P2.234)" @default.
- W2786864544 hasPublicationYear "2017" @default.
- W2786864544 type Work @default.
- W2786864544 sameAs 2786864544 @default.
- W2786864544 citedByCount "0" @default.
- W2786864544 crossrefType "journal-article" @default.
- W2786864544 hasAuthorship W2786864544A5050800806 @default.
- W2786864544 hasAuthorship W2786864544A5080664278 @default.
- W2786864544 hasAuthorship W2786864544A5082915951 @default.
- W2786864544 hasConcept C15744967 @default.
- W2786864544 hasConcept C169760540 @default.
- W2786864544 hasConcept C2778139780 @default.
- W2786864544 hasConcept C2778186239 @default.
- W2786864544 hasConcept C2778802184 @default.
- W2786864544 hasConcept C2780836401 @default.
- W2786864544 hasConcept C42219234 @default.
- W2786864544 hasConcept C71924100 @default.
- W2786864544 hasConcept C98274493 @default.
- W2786864544 hasConceptScore W2786864544C15744967 @default.
- W2786864544 hasConceptScore W2786864544C169760540 @default.
- W2786864544 hasConceptScore W2786864544C2778139780 @default.
- W2786864544 hasConceptScore W2786864544C2778186239 @default.
- W2786864544 hasConceptScore W2786864544C2778802184 @default.
- W2786864544 hasConceptScore W2786864544C2780836401 @default.
- W2786864544 hasConceptScore W2786864544C42219234 @default.
- W2786864544 hasConceptScore W2786864544C71924100 @default.
- W2786864544 hasConceptScore W2786864544C98274493 @default.
- W2786864544 hasLocation W27868645441 @default.
- W2786864544 hasOpenAccess W2786864544 @default.
- W2786864544 hasPrimaryLocation W27868645441 @default.
- W2786864544 hasRelatedWork W1584659697 @default.
- W2786864544 hasRelatedWork W1590926633 @default.
- W2786864544 hasRelatedWork W1961912361 @default.
- W2786864544 hasRelatedWork W1965703970 @default.
- W2786864544 hasRelatedWork W2063357790 @default.
- W2786864544 hasRelatedWork W2072563098 @default.
- W2786864544 hasRelatedWork W2081692935 @default.
- W2786864544 hasRelatedWork W2088120970 @default.
- W2786864544 hasRelatedWork W2090025584 @default.
- W2786864544 hasRelatedWork W2145363840 @default.
- W2786864544 hasRelatedWork W2185129521 @default.
- W2786864544 hasRelatedWork W2398173542 @default.
- W2786864544 hasRelatedWork W2411941462 @default.
- W2786864544 hasRelatedWork W2751952805 @default.
- W2786864544 hasRelatedWork W2806253843 @default.
- W2786864544 hasRelatedWork W2885316831 @default.
- W2786864544 hasRelatedWork W2903657439 @default.
- W2786864544 hasRelatedWork W2938913694 @default.
- W2786864544 hasRelatedWork W2110960367 @default.
- W2786864544 hasRelatedWork W2739980779 @default.
- W2786864544 hasVolume "88" @default.
- W2786864544 isParatext "false" @default.
- W2786864544 isRetracted "false" @default.
- W2786864544 magId "2786864544" @default.
- W2786864544 workType "article" @default.