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• W2786897800 endingPage "52" @default.
• W2786897800 startingPage "27" @default.
• W2786897800 abstract "The efficacy, safety and immunogenicity risk of switching between an originator biologic and a biosimilar or from one biosimilar to another are of potential concern.The aim was to conduct a systematic literature review of the outcomes of switching between biologics and their biosimilars and identify any evidence gaps.A systematic literature search was conducted in PubMed, EMBASE and Cochrane Library from inception to June 2017. Relevant societal meetings were also checked. Peer-reviewed studies reporting efficacy and/or safety data on switching between originator and biosimilar products or from one biosimilar to another were selected. Studies with fewer than 20 switched patients were excluded. Data were extracted on interventions, study population, reason for treatment switching, efficacy outcomes, safety and anti-drug antibodies.The systematic literature search identified 63 primary publications covering 57 switching studies. The reason for switching was reported as non-medical in 50 studies (23 clinical, 27 observational). Seven studies (all observational) did not report whether the reasons for switching were medical or non-medical. In 38 of the 57 studies, fewer than 100 patients were switched. Follow-up after switching went beyond 1 year in eight of the 57 studies. Of the 57 studies, 33 included statistical analysis of disease activity or patient outcomes; the majority of these studies found no statistically significant differences between groups for main efficacy parameters (based on P < 0.05 or predefined acceptance ranges), although some studies observed changes for some parameters. Most studies reported similar safety profiles between groups.There are important evidence gaps around the safety of switching between biologics and their biosimilars. Sufficiently powered and appropriately statistically analysed clinical trials and pharmacovigilance studies, with long-term follow-ups and multiple switches, are needed to support decision-making around biosimilar switching." @default.
• W2786897800 created "2018-02-23" @default.
• W2786897800 creator A5003569285 @default.
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• W2786897800 date "2018-01-17" @default.
• W2786897800 modified "2023-10-06" @default.
• W2786897800 title "Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review" @default.
• W2786897800 cites W1176283365 @default.
• W2786897800 cites W122269675 @default.
• W2786897800 cites W1485765397 @default.
• W2786897800 cites W1520693665 @default.
• W2786897800 cites W1551781971 @default.
• W2786897800 cites W1560551965 @default.
• W2786897800 cites W1654227300 @default.
• W2786897800 cites W1827882046 @default.
• W2786897800 cites W1851453522 @default.
• W2786897800 cites W1855478184 @default.
• W2786897800 cites W1893780198 @default.
• W2786897800 cites W1925922300 @default.
• W2786897800 cites W1963756565 @default.
• W2786897800 cites W1967330974 @default.
• W2786897800 cites W1977123599 @default.
• W2786897800 cites W1979224380 @default.
• W2786897800 cites W1986159244 @default.
• W2786897800 cites W1989217623 @default.
• W2786897800 cites W1996429338 @default.
• W2786897800 cites W1997653630 @default.
• W2786897800 cites W2011931673 @default.
• W2786897800 cites W2024082229 @default.
• W2786897800 cites W2027927088 @default.
• W2786897800 cites W2034110300 @default.
• W2786897800 cites W2036508874 @default.
• W2786897800 cites W2040867432 @default.
• W2786897800 cites W2046477302 @default.
• W2786897800 cites W2057390178 @default.
• W2786897800 cites W2065055449 @default.
• W2786897800 cites W2078353854 @default.
• W2786897800 cites W2100421036 @default.
• W2786897800 cites W2103735104 @default.
• W2786897800 cites W2106152050 @default.
• W2786897800 cites W2110732019 @default.
• W2786897800 cites W2111046066 @default.
• W2786897800 cites W2121690674 @default.
• W2786897800 cites W2124847934 @default.
• W2786897800 cites W2130173462 @default.
• W2786897800 cites W2132392782 @default.
• W2786897800 cites W2135819931 @default.
• W2786897800 cites W2136700413 @default.
• W2786897800 cites W2140035322 @default.
• W2786897800 cites W2140451842 @default.
• W2786897800 cites W2149065814 @default.
• W2786897800 cites W2149858688 @default.
• W2786897800 cites W2161248953 @default.
• W2786897800 cites W2175291039 @default.
• W2786897800 cites W2178617876 @default.
• W2786897800 cites W2188249603 @default.
• W2786897800 cites W2266043674 @default.
• W2786897800 cites W2267224379 @default.
• W2786897800 cites W2279977120 @default.
• W2786897800 cites W2287727839 @default.
• W2786897800 cites W2291327653 @default.
• W2786897800 cites W2293557195 @default.
• W2786897800 cites W2293590090 @default.
• W2786897800 cites W2320750953 @default.
• W2786897800 cites W2321921836 @default.
• W2786897800 cites W2329026548 @default.
• W2786897800 cites W2333884209 @default.
• W2786897800 cites W2336913991 @default.
• W2786897800 cites W2342216265 @default.
• W2786897800 cites W2342464058 @default.
• W2786897800 cites W2345220764 @default.
• W2786897800 cites W2345817342 @default.
• W2786897800 cites W2413180960 @default.
• W2786897800 cites W2414366951 @default.
• W2786897800 cites W2414751009 @default.
• W2786897800 cites W2482832580 @default.
• W2786897800 cites W2495543595 @default.
• W2786897800 cites W2508045778 @default.
• W2786897800 cites W2513482627 @default.
• W2786897800 cites W2521883132 @default.
• W2786897800 cites W2543281533 @default.
• W2786897800 cites W2550409100 @default.
• W2786897800 cites W2550699063 @default.
• W2786897800 cites W2551295995 @default.
• W2786897800 cites W2551989327 @default.
• W2786897800 cites W2555761630 @default.
• W2786897800 cites W2574068890 @default.
• W2786897800 cites W2578994901 @default.
• W2786897800 cites W2581281042 @default.
• W2786897800 cites W2581549770 @default.
• W2786897800 cites W2586796756 @default.
• W2786897800 cites W2593211227 @default.
• W2786897800 cites W2593580677 @default.

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