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• W2787012987 abstract "We have isolated a rat cDNA clone that displays 75% amino acid homology with the mouse δ and rat κ opioid receptors. The cDNA (designated pRMuR-12) encodes a protein of 398 amino acids comprising, in part, seven hydrophobic domains similar to those described for other G protein-linked receptors. Data from binding assays conducted with COS-1 cells transiently transfected with a CMV mammalian expression vector containing the full coding region of pRMuR-12 demonstrated μ receptor selectivity. In situ hybridization mRNA analysis revealed an mRNA distribution in rat brain that corresponds well to the distribution of binding sites labeled with μ-selective ligands. Based upon these observations, we conclude that pRMuR-12 encodes a μ opioid receptor." @default.
• W2787012987 created "2018-02-23" @default.
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• W2787012987 date "1993-11-01" @default.
• W2787012987 modified "2023-09-26" @default.
• W2787012987 title "Cloning and pharmacological characterization of a rat μ opioid receptor" @default.
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• W2787012987 doi "https://doi.org/10.1016/0896-6273(93)90120-g" @default.
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